The progress of clinical research on the detection of 1,5-anhydroglucitol in diabetes and its complications

• Published in: Frontiers in endocrinology (Lausanne) Vol. 15; p. 1383483
• Main Authors: Xu, Huijuan, Pan, Junhua, Chen, Qiu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.05.2024
• Subjects: 1,5-Anhydroglucitol; Biomarkers - analysis; Biomarkers - blood; Blood Glucose - analysis; Blood Glucose - metabolism; blood glucose monitoring; Blood Glucose Self-Monitoring - methods; Deoxyglucose; diabetes; diabetes complications; Diabetes Complications - blood; Diabetes Complications - diagnosis; Diabetes Complications - metabolism; diabetes management; Diabetes Mellitus - blood; Diabetes Mellitus - diagnosis; Diabetes Mellitus - metabolism; Endocrinology; Humans; screen for diabetes; screen for diabetes; diabetes management; diabetes complications; 1,5-Anhydroglucitol; diabetes; blood glucose monitoring
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2024.1383483

1,5-Anhydroglucitol (1,5-AG) is sensitive to short-term glucose fluctuations and postprandial hyperglycemia, which has great potential in the clinical application of diabetes as a nontraditional blood glucose monitoring indicator. A large number of studies have found that 1,5-AG can be used to screen for diabetes, manage diabetes, and predict the perils of diabetes complications (diabetic nephropathy, diabetic cardiovascular disease, diabetic retinopathy, diabetic pregnancy complications, diabetic peripheral neuropathy, etc.). Additionally, 1,5-AG and β cells are also associated with each other. As a noninvasive blood glucose monitoring indicator, salivary 1,5-AG has much more benefit for clinical application; however, it cannot be ignored that its detection methods are not perfect. Thus, a considerable stack of research is still needed to establish an accurate and simple enzyme assay for the detection of salivary 1,5-AG. More clinical studies will also be required in the future to confirm the normal reference range of 1,5-AG and its role in diabetes complications to further enhance the blood glucose monitoring system for diabetes.