Bladder Cancer Mortality in the United States, 1951-1989: Increased Environmental Carcinogenesis in Men

• Published in: Regulatory toxicology and pharmacology Vol. 20; no. 2; pp. 187 - 197
• Main Author: Riggs, J.E.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.10.1994; Elsevier
• Subjects: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Biological and medical sciences; Carcinogens; Child; Child, Preschool; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Infant; Kidneys; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Sex Factors; Time Factors; Tumors of the urinary system; United States - epidemiology; Urinary Bladder Neoplasms - epidemiology; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - mortality; United States; North America; America; USA; Human; Carcinogen; Urinary system disease; Urinary bladder; Mortality; Malignant tumor; Epidemiology; Public health
• ISSN: 0273-2300; 1096-0295
• DOI: 10.1006/rtph.1994.1069

Bladder cancer has been frequently associated with occupational chemical carcinogens. Increased occupational exposures may, in part, account for the increased risk of bladder cancer consistently observed in men. Age-specific bladder cancer mortality rates in the United States from 1951 to 1988 were analyzed using the Strehler-Mildvan modification of the Gompertz relationship between aging and mortality. This method of analysis, which distinguishes aggregate environmental and genetic influences upon mortality, also suggests that environmental influences upon bladder cancer mortality are significantly greater in U.S. men.