Controllable precipitation of naproxen micro-particles with different morphologies

• Published in: Particuology Vol. 10; no. 5; pp. 634 - 643
• Main Authors: Cheng, Peng, Jin, Kangkang, Cheng, Jing, Yang, Fang, Shen, Zhigang, Chen, Jianfeng, Wen, Lixiong
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2012; State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China%Research Center of the Ministry of Education for High Gravity Engineering & Technology, Beijing University of Chemical Technology, Beijing 100029, China%State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China; Research Center of the Ministry of Education for High Gravity Engineering & Technology, Beijing University of Chemical Technology, Beijing 100029, China
• Subjects: Crystal growth; Crystals; Microscopy; Microstructure; Morphology; Naproxen; Precipitation; Stability; Surfactants; 可控; 形貌; 微观粒子; 沉淀法; 药物浓度; 萘普生; 表面活性剂; 降水过程; Crystal growth; Precipitation; Surfactants; Naproxen
• ISSN: 1674-2001; 2210-4291
• DOI: 10.1016/j.partic.2012.04.004

A simple precipitation method was proposed to prepare naproxen micro-particles with different controllable morphologies, using capillary video microscopy to study the precipitation process. Different particle shapes were obtained including spherical, platelet-like, stick-like, needle-like, and butterfly-like, all in the micro-size range. It was found that the sizes and morphologies of the formed naproxen particles were sensitive to the nature and concentration of the added surfactant, and depended significantly on processing conditions such as temperature, stirring speed, and initial drug concentration. In addition, pre- cipitation with different surfactant types and concentrations would not affect the crystal microstructure of the formed nanroxen oarticles.