A South African Indian population group dataset for breast cancer and BRCA1/2 variants

• Published in: Data in brief Vol. 42; p. 108180
• Main Authors: Combrink, H.M.V.E., van der Merwe, N.C., Katarya, R., de Wet, K., Motloung, M.H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.06.2022; Elsevier
• Subjects: BRCA1/2; Breast cancer; Cancer stage; Cancer type; Data; Ethnic group; Ovarian cancer; Pathogenic mutation status; Polymorphisms; VUS; Cancer stage; BRCA1/2; VUS; Cancer type; Breast cancer; Polymorphisms; Pathogenic mutation status; Ethnic group; Ovarian cancer
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2022.108180

No datasets are available on the basis of confirmed familial breast cancer patients and their respective mutation status for the South African Indian population. This dataset contains information collected in South Africa specifically for the South African Indian population (n = 223). The data involved a combined collection of laboratory confirmed genetic testing results, accompanied by immunohistochemical and anatomical pathology results. Various patient self-identified variables were also in measured. All the immunohistochemistry and anatomical pathology results were confirmed by a trained medical pathologist. Furthermore, mutation status and the detection of either benign polymorphisms or variants with an unknown clinical significance at the time of data collection were also reported. This dataset contains variables in a tabular format which includes the accompanying variables for each patient. All the patient-specific data were deidentified which allows for further exploration of the data with respect to the demography, immunohistochemistry and genetic material. This dataset has the potential to serve as the backbone for translational research and inquiries into this unique South African population.