Nephrotoxicity associated with anticancer agents: perspective on onconephrology from nephrologists

Nephrotoxicity is one of the most important complications in cancer patients. In particular, acute kidney injury (AKI) is known to be associated with discontinuing effective oncological treatments, longer hospitalizations, increased costs, and a higher risk of death. In addition to acute kidney inju...

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Published inInternational journal of clinical oncology Vol. 28; no. 5; pp. 625 - 636
Main Authors Matsubara, Takeshi, Yokoi, Hideki, Yamada, Hiroyuki, Yanagita, Motoko
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.05.2023
Springer Nature B.V
Subjects
Acute Kidney Injury - chemically induced
Acute Kidney Injury - epidemiology
Antineoplastic Agents - adverse effects
Antitumor agents
Cancer Research
Cancer therapies
Electrolytes
Epidemiology
Humans
Hypertension
Invited Review Article
Kidney diseases
Medicine
Medicine & Public Health
Neoplasms - complications
Neoplasms - drug therapy
Nephrologists
Nephrology
Nonsteroidal anti-inflammatory drugs
Oncology
Patients
Proteinuria
Proteinuria - chemically induced
Surgical Oncology
Vascular endothelial growth factor
Acute interstitial nephritis (AIN)
Thrombotic microangiopathy (TMA)
Acute kidney injury (AKI)
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Summary:Nephrotoxicity is one of the most important complications in cancer patients. In particular, acute kidney injury (AKI) is known to be associated with discontinuing effective oncological treatments, longer hospitalizations, increased costs, and a higher risk of death. In addition to acute kidney injury, clinical signs associated with nephrotoxicity during treatment with anticancer agents include chronic kidney disease, proteinuria, hypertension, electrolyte abnormalities, and other characteristic manifestations. Many of these signs are caused both by cancer treatment as well as by cancer itself. Therefore, it is important to carefully recognize whether the underlying causes of renal impairment in cancer patients are cancer-related, treatment-related, or both. This review describes the epidemiology and pathophysiology of anticancer agent-induced acute kidney injury, proteinuria, hypertension, and other characteristic manifestations.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-023-02307-z