Study of the Effect of Route of Administration of Mesenchymal Stem Cells on Cisplatin-Induced Acute Kidney Injury in Sprague Dawley Rats
Mesenchymal stem cells (MSCs) have been shown to ameliorate cisplatin-induced acute kidney injury (AKI). The present study compares the efficacy of different routes of MSCs administration on kidney damage and regeneration after cisplatin-induced AKI. A single intraperitoneal injection of cisplatin (...
Saved in:
Published in | International journal of stem cells Vol. 9; no. 1; pp. 79 - 89 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
Korean Society for Stem Cell Research
30.05.2016
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Mesenchymal stem cells (MSCs) have been shown to ameliorate cisplatin-induced acute kidney injury (AKI). The present study compares the efficacy of different routes of MSCs administration on kidney damage and regeneration after cisplatin-induced AKI.
A single intraperitoneal injection of cisplatin (5 mg/kg) was used to induce AKI in 160 rats. MSCs (5×10⁶) were given by either intravenous, intra-arterial or kidney sub capsular injection one day after cisplatin injection. Suitable control groups were included. Rats were sacrificed at 4, 7, 11 and 30 days after cisplatin injection. Kidney function parameters, kidney tissue oxidative stress markers, and scoring for renal tissue injury, regeneration and chronicity were all determined.
MSCs by any routes were able to ameliorate kidney function deterioration and renal tissue damage induced by cisplatin. The overall results of the three routes were equal. Differences between the different routes in one parameter were transient and inconsistent with other parameters.
Changing the route of MSCs injection does not have a major influence on the outcome. Future evaluation should focus on differences between the routes of administration considering the long term safety. |
---|---|
AbstractList | Mesenchymal stem cells (MSCs) have been shown to ameliorate cisplatin-induced acute kidney injury (AKI). The present study compares the efficacy of different routes of MSCs administration on kidney damage and regeneration after cisplatin-induced AKI.
A single intraperitoneal injection of cisplatin (5 mg/kg) was used to induce AKI in 160 rats. MSCs (5×10⁶) were given by either intravenous, intra-arterial or kidney sub capsular injection one day after cisplatin injection. Suitable control groups were included. Rats were sacrificed at 4, 7, 11 and 30 days after cisplatin injection. Kidney function parameters, kidney tissue oxidative stress markers, and scoring for renal tissue injury, regeneration and chronicity were all determined.
MSCs by any routes were able to ameliorate kidney function deterioration and renal tissue damage induced by cisplatin. The overall results of the three routes were equal. Differences between the different routes in one parameter were transient and inconsistent with other parameters.
Changing the route of MSCs injection does not have a major influence on the outcome. Future evaluation should focus on differences between the routes of administration considering the long term safety. BACKGROUND AND OBJECTIVESMesenchymal stem cells (MSCs) have been shown to ameliorate cisplatin-induced acute kidney injury (AKI). The present study compares the efficacy of different routes of MSCs administration on kidney damage and regeneration after cisplatin-induced AKI.METHODSA single intraperitoneal injection of cisplatin (5 mg/kg) was used to induce AKI in 160 rats. MSCs (5×10⁶) were given by either intravenous, intra-arterial or kidney sub capsular injection one day after cisplatin injection. Suitable control groups were included. Rats were sacrificed at 4, 7, 11 and 30 days after cisplatin injection. Kidney function parameters, kidney tissue oxidative stress markers, and scoring for renal tissue injury, regeneration and chronicity were all determined.RESULTSMSCs by any routes were able to ameliorate kidney function deterioration and renal tissue damage induced by cisplatin. The overall results of the three routes were equal. Differences between the different routes in one parameter were transient and inconsistent with other parameters.CONCLUSIONSChanging the route of MSCs injection does not have a major influence on the outcome. Future evaluation should focus on differences between the routes of administration considering the long term safety. |
Author | Mahmoud, Khalid Khater, Youmna Abouelkheir, Mohamed Moustafa, Fatma E Sobh, Mohamed-A Saad, Mohamed-Ahdy Sobh, Mohamed A |
AuthorAffiliation | 4 Mansoura Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt 3 Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt 1 Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt 2 Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt |
AuthorAffiliation_xml | – name: 1 Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt – name: 4 Mansoura Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt – name: 2 Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt – name: 3 Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt |
Author_xml | – sequence: 1 givenname: Fatma E surname: Moustafa fullname: Moustafa, Fatma E organization: Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 2 givenname: Mohamed-A surname: Sobh fullname: Sobh, Mohamed-A organization: Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 3 givenname: Mohamed surname: Abouelkheir fullname: Abouelkheir, Mohamed organization: Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 4 givenname: Youmna surname: Khater fullname: Khater, Youmna organization: Mansoura Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 5 givenname: Khalid surname: Mahmoud fullname: Mahmoud, Khalid organization: Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 6 givenname: Mohamed-Ahdy surname: Saad fullname: Saad, Mohamed-Ahdy organization: Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 7 givenname: Mohamed A surname: Sobh fullname: Sobh, Mohamed A organization: Mansoura Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27426089$$D View this record in MEDLINE/PubMed |
BookMark | eNpVUU1v1DAQtVARLaU_gAvykUuCHTsfviCtlgIripC6cLa89rjrVWIvsQPKP-jPrkOXCnzxeN6b55l5L9GZDx4Qek1JSeuqY-_cIeqyIrQpRUnLVjxDFxUhdVFz3p6dYtaQ5hxdxXgg-TDRiaZ7gc6rllcN6cQFut-mycw4WJz2gK-tBZ2W122YEizBygzOu5hGlVzwS-YrRPB6Pw-qx9sEA15D30ecwbWLxz7zfLHxZtJg8EovMl-c8TDjjT9M44ydx9vjqO4mwB_U7z4DtyrFV-i5VX2Eq9N9iX58vP6-_lzcfPu0Wa9uCs2ESEVFrDaigdpwC9bo2lQ1cCY0g45UtNNEQR5Om5YZvduRnWpA5U1YWwEnLWeX6P2j7nHaDWA0-DxaL4-jG9Q4y6Cc_B_xbi_vwi_JRUMpabPA25PAGH5OEJMcXNR5BcpDmKKkHal5xzitM5U-UvUYYhzBPn1DifxjolxMlIuJUkgqW5Fr3vzb31PFX8vYA1Pwnfg |
CitedBy_id | crossref_primary_10_1016_j_jcyt_2017_10_003 crossref_primary_10_1097_IMNA_D_22_00014 crossref_primary_10_1111_apm_13352 crossref_primary_10_1186_s13020_022_00574_y crossref_primary_10_1007_s11010_022_04421_4 crossref_primary_10_14202_vetworld_2022_2475_2490 crossref_primary_10_1186_s13287_021_02374_x crossref_primary_10_1016_j_jchemneu_2018_06_003 crossref_primary_10_15171_PS_2018_15 crossref_primary_10_3389_fmed_2018_00179 crossref_primary_10_3390_ijms19092564 crossref_primary_10_3390_ijms19071853 crossref_primary_10_1155_2020_8819757 crossref_primary_10_3389_fphar_2023_1099056 crossref_primary_10_1016_j_semperi_2023_151727 crossref_primary_10_1155_2017_7304643 crossref_primary_10_1016_j_phymed_2023_154809 crossref_primary_10_1016_j_jff_2023_105504 crossref_primary_10_3390_biomedicines10061295 crossref_primary_10_3390_scipharm90040058 |
ContentType | Journal Article |
Copyright | Copyright ©2016, Korean Society for Stem Cell Research 2016 |
Copyright_xml | – notice: Copyright ©2016, Korean Society for Stem Cell Research 2016 |
DBID | NPM AAYXX CITATION 7X8 5PM |
DOI | 10.15283/ijsc.2016.9.1.79 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 2005-5447 |
EndPage | 89 |
ExternalDocumentID | 10_15283_ijsc_2016_9_1_79 27426089 |
Genre | Journal Article |
GroupedDBID | 5-W 53G 8JR ADBBV ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL DIK EF. FRP GX1 HYE NPM OK1 RPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c399t-20fcd96e5d4fefdc5d25e439c3e80218c0ae742cd73dcbb0ba6ea005ff2e40743 |
IEDL.DBID | RPM |
ISSN | 2005-3606 |
IngestDate | Fri Sep 01 02:16:14 EDT 2023 Thu May 30 23:46:22 EDT 2024 Fri Aug 23 03:31:01 EDT 2024 Wed Oct 09 10:20:54 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | Routes of administration Sub capsular Acute kidney injury Cisplatin Mesenchymal stem cells |
Language | English |
License | This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c399t-20fcd96e5d4fefdc5d25e439c3e80218c0ae742cd73dcbb0ba6ea005ff2e40743 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961107/ |
PMID | 27426089 |
PQID | 1805483415 |
PQPubID | 23479 |
PageCount | 11 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4961107 proquest_miscellaneous_1805483415 crossref_primary_10_15283_ijsc_2016_9_1_79 pubmed_primary_27426089 |
PublicationCentury | 2000 |
PublicationDate | 2016-May-30 |
PublicationDateYYYYMMDD | 2016-05-30 |
PublicationDate_xml | – month: 05 year: 2016 text: 2016-May-30 day: 30 |
PublicationDecade | 2010 |
PublicationPlace | Korea (South) |
PublicationPlace_xml | – name: Korea (South) |
PublicationTitle | International journal of stem cells |
PublicationTitleAlternate | Int J Stem Cells |
PublicationYear | 2016 |
Publisher | Korean Society for Stem Cell Research |
Publisher_xml | – name: Korean Society for Stem Cell Research |
SSID | ssj0000398968 |
Score | 2.1941874 |
Snippet | Mesenchymal stem cells (MSCs) have been shown to ameliorate cisplatin-induced acute kidney injury (AKI). The present study compares the efficacy of different... BACKGROUND AND OBJECTIVESMesenchymal stem cells (MSCs) have been shown to ameliorate cisplatin-induced acute kidney injury (AKI). The present study compares... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 79 |
SubjectTerms | Original |
Title | Study of the Effect of Route of Administration of Mesenchymal Stem Cells on Cisplatin-Induced Acute Kidney Injury in Sprague Dawley Rats |
URI | https://www.ncbi.nlm.nih.gov/pubmed/27426089 https://www.proquest.com/docview/1805483415/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC4961107 |
Volume | 9 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLXWPfGCQHyVwWQknpCSJk3szI9TYQxQEWJM6pvl2NcsU-tWSyrUf8DP5l63mVp44y2JkyvLx7GP7eNjxt6Kos5sZspEGUWzVU4ldVlkic8lcrncj01UVU6_ysvr8vNMzI6Y6PfCRNG-rZs0zBdpaG6itnK1sKNeJzb6Np2UStKwZTRgg6oo9obosfkt1JmKW-Ciy2aBDH23mkk-JqPmtiXnwlymKs3TilxDabVSZnTQ-37X9A_f_Fs2udcPXTxiD3cEkp9vM_qYHUF4wn6THHDDl54jn-NbR2K6I70P0MWhRy49mdK2I3uzWWCwqw4WfALzecsxcdK0K1LIhYTO9bDg-LmlMF8aF2DDP4VbxIE3gV-t7szPNfD35hc2Lfy76dqn7Priw4_JZbI7YyGxSE06_Em8dUqCcKUH76xwYwFIUmwBZ9T9I46AxWNdVThb11ltJBgsV-_HUBL9eMaOwzLAC8ZdCUgWkS5kCoNVRmFBSWnIY04IX_ghe9cXr15trTQ0DUEIFk2waIJFK53rSg3Zmx4AjRWeVjFMgOW61RSOZkBzMWTPt4Dch-uRHLLqAKr7F8hM-zAF61g01d7VqZf__eUJe0D5j8qC7BU77u7W8BoJS1efssHHWX4aq-kfLQ7tHg |
link.rule.ids | 230,315,733,786,790,891,27957,27958,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwGLXGeIAXBuJWxsVIPCElTZrYmR-nwtSxdUJsQ3uzHF-2jNatllSo_AJ-Nt_nNFM7nuAtiZNPco4vx_bxMSEfWFYmOlF5JJTA2SojojLPksilHLhc6gYqqCrHJ3x0nn-5YBdbhHV7YYJoX5dV7CfT2FdXQVs5n-p-pxPrfx0Pc8Fx2NK_R-5DfR0Ua4P00ABnYk-ETXDBZzMDjr5az0Qnk351XaN3YcpjEadxgb6huF7JEzzqfb1z-otx3hVOrvVEBzvke5eHVoDyI140Zax_3bF3_OdMPiaPVtyU7rfJT8iW9U_Jb1QaLunMUaCKtDU7xjuUElm82LTfxSdj3NGkr5ZTCHba2Ckd2smkppA4rOo5iu98hEeGaGvovsYwR5XxdkkP_TVATCtPT-c36nJh6Sf1E1ot-k019TNyfvD5bDiKVsc3RBpYTwP1z2kjuGUmd9YZzcyAWeA_OrN7yCygiFj479oUmdFlmZSKWwWAOTewOTKb52Tbz7x9SajJLfBQYCKJgGCFEoAA5wrt6xhzmeuRjx1uct66dEgc3SDeEvGWiLcUMpWF6JH3HbIS6hIukChvZ4taYjicXE1Zj7xokb4N1xWRHik2ysDtC-jTvZkCyAa_7hWSr_77y3fkwehsfCyPD0-OdslDzEsQMCSvyXZzs7BvgBc15dtQC_4AyW8OMA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwGLVgSIgX2MStwJiReELKrUmc-XHqqDZGp4kxaeLFcnxhGa0bLalQ-QX8bL7PaaZ2vO0tiZ1Pco7tHNvHx4R8zNMyVrHMAi45zlZpHpRZGgc2YcDlEjuUXlU5OWVHF9mXy_xy7agvL9pXZRW66Sx01ZXXVtYzFfU6sehsMso4w2FLVGsbPSSPoM0O-dpA3XfCKd_nfiOc99pMgaev1jTRzSSqrhv0L0xYyMMkLNA7FNcsWYzHva__oP5jnXfFk2t_o_Ez8qMvRydC-RUu2jJUf-5YPN6roNvk6Yqj0oMuyw55YNxz8hcVh0s6txQoI-1Mj_EOJUUGLzZtePHJBHc2qavlDIKdt2ZGR2Y6bSgkjqqmRhGeC_DoEGU0PVAY5qTSzizpsbsGqGnl6Hl9I38uDD2Uv6H3ot9k27wgF-PP30dHweoYh0AB-2mhHVqlOTO5zqyxWuV6mBvgQSo1-8gwoKoY-PZKF6lWZRmXkhkJoFk7NBkynJdky82deU2ozgzwUWAkMYdgheSAAmMSbezy3KZ2QD712Im6c-sQOMpBzAViLhBzwUUiCj4gH3p0BbQpXCiRzswXjcBwOMma5APyqkP7NlxfTQak2KgHtxnQr3szBdD1vt0rNN_c-8098vjscCy-Hp-evCVPsChexxC_I1vtzcLsAj1qy_e-IfwDMH0QsA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Study+of+the+Effect+of+Route+of+Administration+of+Mesenchymal+Stem+Cells+on+Cisplatin-Induced+Acute+Kidney+Injury+in+Sprague+Dawley+Rats&rft.jtitle=International+journal+of+stem+cells&rft.au=Moustafa%2C+Fatma+E&rft.au=Sobh%2C+Mohamed-A&rft.au=Abouelkheir%2C+Mohamed&rft.au=Khater%2C+Youmna&rft.date=2016-05-30&rft.issn=2005-3606&rft.volume=9&rft.issue=1&rft.spage=79&rft_id=info:doi/10.15283%2Fijsc.2016.9.1.79&rft_id=info%3Apmid%2F27426089&rft.externalDocID=27426089 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2005-3606&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2005-3606&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2005-3606&client=summon |