Pattern of the ventilatory response to transient hypoxia in man: differences from transient hypercapnic test

The pattern of change in ventilatory variables after inhalation of pure N2 for two breaths was studied in normal children and adults. In six subjects the trends of change were compared to the ventilatory response to transient hypercapnia. We observed differences in the patterns of increasing ventila...

Full description

Saved in:
Bibliographic Details
Published inArchives internationales de physiologie et de biochimie Vol. 87; no. 2; p. 229
Main Authors Jammes, Y, Fornaris, M, Guillot, C, Grimaud, C
Format Journal Article
LanguageEnglish
Published Belgium 01.01.1979
Subjects
Adult
Carbon Dioxide
Child
Female
Humans
Hypercapnia - physiopathology
Hypoxia - physiopathology
Male
Middle Aged
Nitrogen
Respiration
Online AccessGet more information

Cover

More Information
Summary:The pattern of change in ventilatory variables after inhalation of pure N2 for two breaths was studied in normal children and adults. In six subjects the trends of change were compared to the ventilatory response to transient hypercapnia. We observed differences in the patterns of increasing ventilation with an initial abrupt increase of tidal volume for transient hypoxia and a progressive change for hypercapnia. In both cases respiratory frequency was progressively but unsystematically enhanced. A highly significant positive correlation was demonstrated between individual sensitivities to CO2 and O2, with a greater response to hypercapnia (5.6 time) than to hypoxia. Finally, a very short-latency decrease in expiratory duration occurred in the first breath after inhalation of hypercapnic mixture, supporting the recent data of Cunningham et al. (1977).
ISSN:0003-9799
DOI:10.3109/13813457909070496