X inactivation and progenitor cancer cells

In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenito...

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Bibliographic Details
Published inCancers Vol. 3; no. 2; pp. 2169 - 2175
Main Author Agrelo, Ruben
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 26.04.2011
Molecular Diversity Preservation International (MDPI)
Subjects
cancer
chromatin
epigenetics
Review
X inactivation
Xist RNA
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Summary:In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers3022169