Poly (glycerol sebacate) – co – 2 – hydroxyethyl methacrylate bioelastomeric nanohydroxyapatite composites: Mechanical properties, thermal characteristics, and cytocompatibility studies

• Published in: Polymer engineering and science Vol. 64; no. 6; pp. 2404 - 2419
• Main Authors: Roy, Pratik, Sailaja, R. R. N.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2024; Society of Plastics Engineers, Inc; Blackwell Publishing Ltd
• Subjects: Analysis; Apatite; apatite formation; Biocompatibility; bioelastomer; Biomedical materials; Body fluids; Chemical synthesis; Compressive strength; cytocompatibility; Diffraction; Glycerin; Glycerol; In vitro methods and tests; Mechanical properties; Nanocomposites; nanohydroxyapatite; poly (glycerol sebacate); Polycondensation reactions; Polyhydroxyethyl methacrylate; Polymers; Scanning electron microscopy; Sebacic acid; Silane; Water absorption; X-rays; India
• ISSN: 0032-3888; 1548-2634
• DOI: 10.1002/pen.26699

In this study bioelastomeric co‐polymer comprised of glycerol, sebacic acid, and 2‐hydroxyethyl methacrylate, loaded with varied contents of nanohydroxyapatite (0%–8%) has been synthesized via polycondensation reaction. The mechanical properties, that is, tensile and compressive strength and modulus have been enhanced due to the addition of silane‐treated nanohydroxyapatite. The optimal mechanical properties for these nanocomposites have been found to be at 7% nanohydroxyapatite loading. X‐Ray diffraction analysis and scanning electron microscopy (SEM) revealed efficient dispersion of nanohydroxyapatite throughout the matrix as particles and as well as agglomerates. The synthesized composite was found to be cytocompatible and showed excellent biocompatibility by forming thick apatite layers in simulated body fluid. Highlights Synthesis of PGS/nHA bioelastomeric nanocomposite via polycondensation. Characterization of nanocomposite with FTIR, TGA, XRD, SEM, AFM. Water absorption, bioactivity and cytocompatibility assessment. In vitro degradation evaluation. Schematic representation of PGS bioelastomeric composite.