Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia

• Published in: Annals of human genetics Vol. 74; no. 4; pp. 291 - 298
• Main Authors: Novak, Gabriela, LeBlanc, Martha, Zai, Clement, Shaikh, Sajid, Renou, Julien, DeLuca, Vincenzo, Bulgin, Natalie, Kennedy, James L., Le Foll, Bernard
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2010
• Subjects: addiction; association; association analysis; BDNF; Brain-Derived Neurotrophic Factor - genetics; dopamine; DRD1; DRD3; gene; Genetic Association Studies; Genetic Predisposition to Disease; genetic susceptibility; Humans; nicotine; polymorphism; Polymorphism, Single Nucleotide; Receptors, Dopamine D1 - genetics; Receptors, Dopamine D3 - genetics; Risk; Schizophrenia; Schizophrenia - genetics; smoking; Smoking - genetics
• ISSN: 0003-4800; 1469-1809
• DOI: 10.1111/j.1469-1809.2010.00578.x

Summary Emerging evidence indicates that the DRD1‐BDNF‐DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour.