Analysis of CD44 expression in serous and mucinous borderline tumours of the ovary: comparison with cystadenomas and overt carcinomas

Aims: To determine the diagnostic and prognostic value of the immunohistochemical analysis of CD44 variants in benign borderline and malignant tumours of the ovary. Methods and results: The reactivity of tumour cells with three monoclonal antibodies, respectively, directed to all CD44 variants, CD44...

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Published inHistopathology Vol. 32; no. 2; pp. 151 - 159
Main Authors DARAI, E, WALKER-COMBROUZE, F, FAUCONNIER, A, MADELENAT, P, POTET, F, SCOAZEC, J.-Y
Format Journal Article
LanguageEnglish
Published Oxford, U.K. and Cambridge, USA Blackwell Science Ltd 01.02.1998
Blackwell
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Summary:Aims: To determine the diagnostic and prognostic value of the immunohistochemical analysis of CD44 variants in benign borderline and malignant tumours of the ovary. Methods and results: The reactivity of tumour cells with three monoclonal antibodies, respectively, directed to all CD44 variants, CD44‐v3 isoform and CD44‐v6 isoform, was assessed by using an indirect immunoperoxidase technique applied to formalin‐fixed, paraffin‐embedded samples of 36 cases of borderline, as compared to 20 cases of benign tumours and 20 cases of carcinomas. CD44 variants were detected in 97% of borderline tumours, as compared to 60% of benign tumours and 100% of carcinomas. CD44‐v3 was detected in 25% of borderline tumours, as compared to 0% of benign tumours (P = 0.003) and 55% of carcinomas (P = 0.065). The expression of CD44‐v6 was detected in 28% of borderline tumours, as compared to 20% of benign tumours and 30% of carcinomas. In borderline tumours, as in carcinomas, CD44‐v6, but not CD44‐v3, expression was correlated with an increased proliferative index and with a higher incidence of p53 expression. Conclusion: Borderline tumours of the ovary present frequent quantitative and qualitative alterations in the pattern of expression of CD44 proteins. However, these alterations are unlikely to represent useful diagnostic or prognostic markers.
Bibliography:ark:/67375/WNG-D58KQ52F-B
istex:A8FF8B1F0F75D0FBF0FF1589FDC9A1EF0354C7B9
ArticleID:HIS347
ISSN:0309-0167
1365-2559
DOI:10.1046/j.1365-2559.1998.00347.x