Better Survival of Random Pattern Skin Flaps Through the Use of Epigallocatechin Gallate
Background Surgical skin flaps are useful, but flap necrosis is a common problem. Epigallocatechin gallate (EGCG), the major polyphenol of green tea, has been investigated as a neovascularization agent to counteract necrosis. Objectives To evaluate the effect of EGCG on random pattern skin flap surv...
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Published in | Dermatologic surgery Vol. 38; no. 11; pp. 1835 - 1842 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Malden, MA
Wiley
01.11.2012
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Subjects | |
Online Access | Get full text |
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Summary: | Background
Surgical skin flaps are useful, but flap necrosis is a common problem. Epigallocatechin gallate (EGCG), the major polyphenol of green tea, has been investigated as a neovascularization agent to counteract necrosis.
Objectives
To evaluate the effect of EGCG on random pattern skin flap survival.
Materials and Methods
The rat dorsal skin flap model was employed. One hundred rats were divided into five groups of equal size. Experimental Group A received local injection of EGCG to the flap, experimental Group B received topical application of EGCG, control Group C received local injection of saline, control Group D received topical application of an acetone–olive oil mixture, and control Group E received no treatment. The surviving area of the flap, regional blood perfusion, capillary density, and vascular endothelial growth factor (VEGF) expression were evaluated.
Results
We observed a larger area of skin flap survival in Groups A and B than in the control groups. Doppler measurement showed greater perfusion in Groups A and B, and the capillary density and VEGF expression were significantly higher in the experimental animals.
Conclusion
The EGCG treatment enhanced neovascularization and regional perfusion and, as a result, improved skin flap survival. |
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Bibliography: | The authors have indicated no significant interest with commercial supporters . ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1076-0512 1524-4725 |
DOI: | 10.1111/j.1524-4725.2012.02566.x |