X-ray computed microtomography for determination of relationships between structure and breaking of scored tablets
This paper reports on the relationship between the structure and halving properties of scored tablets. The results of the density measurements and structure determination by X‐ray computed microtomography revealed that this analytical technique is very suitable for the investigation of porous struct...
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Published in | X-ray spectrometry Vol. 38; no. 6; pp. 505 - 509 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.11.2009
Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | This paper reports on the relationship between the structure and halving properties of scored tablets. The results of the density measurements and structure determination by X‐ray computed microtomography revealed that this analytical technique is very suitable for the investigation of porous structures and aggregates thanks to its noninvasive character. The results of the analyses show that besides various porosities also big differences exist in the arrangement of the particles inside the comprimates. These basic qualitative differences in the structure of tablets prepared with different tablet presses greatly influence their breaking, and must be taken into consideration during the production of dosage forms. Copyright © 2009 John Wiley & Sons, Ltd. |
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Bibliography: | ArticleID:XRS1205 Sanofi-Aventis scholarship ark:/67375/WNG-VKQRC7VK-C istex:7BBA9F7835EC5CEACA29C95ACE2D09F80F28CFEA ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0049-8246 1097-4539 |
DOI: | 10.1002/xrs.1205 |