X-ray computed microtomography for determination of relationships between structure and breaking of scored tablets

• Published in: X-ray spectrometry Vol. 38; no. 6; pp. 505 - 509
• Main Authors: Sovány, T., Kása Jr, P., Vakli, K., Pintye-Hódi, K.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2009; Wiley
• Subjects: Analytical chemistry; Chemistry; Exact sciences and technology; Dosage form; Tablet; Porosity
• ISSN: 0049-8246; 1097-4539
• DOI: 10.1002/xrs.1205

This paper reports on the relationship between the structure and halving properties of scored tablets. The results of the density measurements and structure determination by X‐ray computed microtomography revealed that this analytical technique is very suitable for the investigation of porous structures and aggregates thanks to its noninvasive character. The results of the analyses show that besides various porosities also big differences exist in the arrangement of the particles inside the comprimates. These basic qualitative differences in the structure of tablets prepared with different tablet presses greatly influence their breaking, and must be taken into consideration during the production of dosage forms. Copyright © 2009 John Wiley & Sons, Ltd.