SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 3-DEOXY-DL-PRUMYCIN ANALOGS

A number of 3-deoxy-DL-prumycin analogues containing one or more amino acid moieties were synthesized. Key intermediate 2 afforded ester analogues by coupling with H-D- or L-Ala-OH, while intermediates 6 and 9 afforded amide analogues by coupling with H-D-Ala-D-Ala-OH, H-D-Ala-OH, 2-amino-4,4-dichlo...

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Published inLiebigs Annalen der Chemie no. 8; pp. 847 - 850
Main Authors CONSTANTINOUKOKOTOU, KOKOTOS, G, CHRYSAYITOKOUSBALIDES, M, COULADOUROS, EA, GEORGIADIS, MP
Format Journal Article
LanguageEnglish
Published DEERFIELD BEACH Wiley 05.08.1994
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
3-DEOXYPRUMYCIN
PEPTIDES
FURANS
PRODUCTS
AMINO ACIDS
PRUMYCIN
ANTIFUNGAL AGENTS
DERIVATIVES
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Summary:A number of 3-deoxy-DL-prumycin analogues containing one or more amino acid moieties were synthesized. Key intermediate 2 afforded ester analogues by coupling with H-D- or L-Ala-OH, while intermediates 6 and 9 afforded amide analogues by coupling with H-D-Ala-D-Ala-OH, H-D-Ala-OH, 2-amino-4,4-dichlorobutanoic acid and acetic acid. The antifungal activity of the analogues against various phytopathogenic fungi was measured.
ISSN:0170-2041
DOI:10.1002/jlac.199419940814