Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study

• Published in: Journal of international medical research Vol. 49; no. 4; p. 3000605211006522
• Main Authors: Zhang, Yaqin, Zhao, Xiaotong, Li, Yongxiang, Wang, Youmin, Chen, Mingwei
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2021; Sage Publications Ltd; SAGE Publishing
• Subjects: Asian Continental Ancestry Group - genetics; Body mass index; Case-Control Studies; China; Colorectal cancer; Colorectal Neoplasms - genetics; Cytokines - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; GPI-Linked Proteins - genetics; Humans; Lectins - genetics; Male; Polymorphism; Polymorphism, Single Nucleotide - genetics; Retrospective Clinical Research Report; China; colorectal cancer; body mass index; Chinese Han; rs2274907; Omentin-1; biomarker; genotype
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/03000605211006522

Objective To explore the relationship between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer (CRC) in the Chinese Han population. Methods rs2274907 A>T was assessed by PCR–restriction fragment length polymorphism analysis. Plasma omentin-1 expression from 358 patients with CRC and 286 healthy controls was analyzed by enzyme-linked immunosorbent assay. CRC and control groups were divided into subgroups according to the body mass index (BMI) threshold of 25 kg/m2. Results No significant differences were observed between CRC and control groups in terms of genotype or allele frequencies of rs2274907 A>T. Compared with individuals with BMI <25 kg/m2 and the rs2274907 TT genotype, those with AA+AT genotypes and BMI ≥25 kg/m2 had a 3.027-fold increased risk of CRC. A significant tendency toward a higher stage of colorectal adenocarcinomas and depth of invasion was observed in individuals with the rs2274907 AA genotype compared with other genotypes. Conclusions The omentin-1 gene rs2274907 A>T polymorphism does not seem to play a critical role in the development of CRC in the Chinese Han population, but an interaction between the rs2274907 A allele and BMI may increase the CRC risk. The rs2274907 AA genotype is a potential biomarker for CRC stage progression.