Effects of manganese chloride on the rat developing nervous system

Sprague-Dawley rats were exposed to sublethal doses of manganese chloride during their postnatal development period up to 44 days of age. They showed transient clinical signs of disease and a decreased homovanillic acid (HVA) content in the striatum and hypothalamus between 15 and 22 days of age. Th...

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Published inActa pharmacologica et toxicologica Vol. 59; no. 5; p. 345
Main Authors Kristensson, K, Eriksson, H, Lundh, B, Plantin, L O, Wachtmeister, L, el Azazi, M, Morath, C, Heilbronn, E
Format Journal Article
LanguageEnglish
Published Denmark 01.11.1986
Subjects
Animals
Brain - drug effects
Brain - growth & development
Brain - metabolism
Chlorides
Electroretinography
Homovanillic Acid - metabolism
Manganese - metabolism
Manganese Compounds
Manganese Poisoning
Rats
Rats, Inbred Strains
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Summary:Sprague-Dawley rats were exposed to sublethal doses of manganese chloride during their postnatal development period up to 44 days of age. They showed transient clinical signs of disease and a decreased homovanillic acid (HVA) content in the striatum and hypothalamus between 15 and 22 days of age. The manganese content in the brain was increased 20-40 times during this period as determined with neutron activation analyses. In spite of this no structural damage or signs of maturation disturbances in the nervous system were found. Interruption of manganese exposure reversed the changes in HVA content.
ISSN:0001-6683
DOI:10.1111/j.1600-0773.1986.tb00182.x