Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer
Using exciton‐coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host–guest complex formed with (+)‐(S)‐methamphetamine produced a negative bisignate...
Saved in:
Published in | Chirality (New York, N.Y.) Vol. 22; no. 4; pp. 398 - 402 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
05.05.2010
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Using exciton‐coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host–guest complex formed with (+)‐(S)‐methamphetamine produced a negative bisignate‐shaped ECCD spectrum, whereas the complex formed with (−)‐(R)‐methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States. Chirality 2010. © 2009 Wiley‐Liss, Inc. |
---|---|
Bibliography: | NSF - No. DUE-0633462; No. CHE-0747949 ark:/67375/WNG-QBRPDPTS-L ArticleID:CHIR20752 NIH (INBRE Program of the National Center for Research Resources) - No. P20 RR016469 istex:604EDD7037B7E1EAFD4AB17EA3035B8A8551D9B5 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0899-0042 1520-636X |
DOI: | 10.1002/chir.20752 |