Antimelanogenic effects of Inula britannica flower petal extract fermented by Lactobacillus plantarum KCCM 11613P
The inhibitory effects of Lactobacillus plantarum -fermented and non-fermented Inula britannica extracts on the tyrosinase activity were comparatively investigated to examine whether and how they improve the whitening activity, and the contents of total flavonoids and polyphenolics as bioactive comp...
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Published in | Journal of Zhejiang University. B. Science Vol. 18; no. 9; pp. 816 - 824 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Hangzhou
Zhejiang University Press
01.09.2017
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | The inhibitory effects of
Lactobacillus plantarum
-fermented and non-fermented
Inula britannica
extracts on the tyrosinase activity were comparatively investigated to examine whether and how they improve the whitening activity, and the contents of total flavonoids and polyphenolics as bioactive compounds were determined. The skin whitening activity using in vitro or ex vivo tyrosinase and L-3,4-dihydroxyphenylalanine (L-DOPA) staining was examined. The total flavonoid content (TFC) was increased by 13.4% after 72 h-fermentation. The viabilities of the B16F10 cells treated with the fermented and non-fermented control extracts were 100.26% and 92.15% at 500 μg/ml, respectively. In addition, the inhibition of tyrosinase activity was increased by the fermented samples from 29.33% to 41.74% following fermentation for up to 72 h. The tyrosinase activity of the untreated control group was increased to 145.69% in B16F10 cells. The results showed that
I. britannica
fermented by
L. plantarum
dose-dependently inhibited tyrosinase activity, which was stimulated by α-melanocyte stimulating hormone. These results suggest that lactic fermented
I. britannica
extracts can be used as effective skin-whitening materials. |
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Bibliography: | Corresponding Author |
ISSN: | 1673-1581 1862-1783 |
DOI: | 10.1631/jzus.B1600234 |