Biochemical and histopathological studies of the PTU-induced hypothyroid rat kidney with reference to the ameliorating role of folic acid

• Published in: Toxicology and industrial health Vol. 29; no. 7; pp. 600 - 608
• Main Authors: Salama, Afrah F, Tousson, Ehab, Ibrahim, Wafaa, Hussein, Wesam M
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2013; Sage Publications Ltd
• Subjects: Acids; Analysis of Variance; Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Cardiovascular system; Creatinine; Creatinine - blood; Drinking water; Folic Acid - pharmacology; Folic Acid - therapeutic use; Growth factors; Homocysteine; Hypothyroidism; Hypothyroidism - chemically induced; Hypothyroidism - drug therapy; Hypothyroidism - metabolism; Kidney - chemistry; Kidney - drug effects; Kidney - pathology; Kidneys; Laboratories; Male; Metabolism; Nitrates; Oxidative stress; Oxidative Stress - drug effects; Plasma; Propylthiouracil - toxicity; Rats; Thyroid gland; Toxicology; Triiodothyronine - blood; Urea - blood; Vitamin B; Weight Gain - drug effects; Zoology; United States > US; Egypt; 6-n-propyl-2-thiouracil; kidney; Hypothyroidism; folic acid
• ISSN: 0748-2337; 1477-0393
• DOI: 10.1177/0748233711432577

Thyroid hormones (THs) are essential for growth and development of the kidney. Also TH influences glomerular filtration and tubular functions. Hypothyroidism negative influences kidney function indirectly by affecting the cardiovascular system and the renal blood flow, and directly by affecting glomerular filtration, tubular functions and the structure of the kidney. The purpose of this study was to evaluate changes in biochemical markers, oxidative stress parameter and histological changes in kidney of hypothyroid rats before and after treatment with folic acid. Hypothyroidism was induced for 6 weeks by the administration of propylthiouracil in drinking water. Urea and creatinine were measured to evaluate the changes in kidney function. Also malondialdehyde, nitrite, nitrate and other oxidative stress parameter were measured in serum and kidney tissue as indicators of oxidative damage. Kidney function and oxidative stress parameters in hypothyroid rats were significantly changed compared to those in control rats. Treatment with folic acid helps in improving the adverse effect of hypothyroidism; the histological study also confirms this finding.