Hydroxypropyl methylcellulose-copper nanoparticle and its nanocomposite hydrogel films for antibacterial application

• Published in: Carbohydrate polymers Vol. 254; p. 117302
• Main Authors: Jayaramudu, Tippabattini, Varaprasad, Kokkarachedu, Pyarasani, Radha D., Reddy, K. Koteshwara, Akbari-Fakhrabadi, A., Carrasco-Sánchez, Verónica, Amalraj, John
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.02.2021
• Subjects: Anti-Bacterial Agents - chemistry; Antibacterial activity; antibacterial properties; ascorbic acid; Ascorbic Acid - chemistry; Bandages; Chemical Precipitation; Copper - chemistry; copper nanoparticles; Escherichia coli; Escherichia coli - drug effects; Hot Temperature; Hydrogel films; hydrogels; Hydrogels - chemistry; Hypromellose Derivatives - chemistry; Metal Nanoparticles - chemistry; methylcellulose; Methylgalactosides - chemistry; Microbial Sensitivity Tests; nanocomposites; Nanocomposites - chemistry; Non-ionic hydroxypropyl methylcellulose; Particle Size; Spherical copper nanoparticles; Staphylococcus aureus - drug effects; Wound Healing - drug effects; Hydrogel films; Non-ionic hydroxypropyl methylcellulose; Antibacterial activity; Spherical copper nanoparticles
• ISSN: 0144-8617; 1879-1344; 1879-1344
• DOI: 10.1016/j.carbpol.2020.117302

[Display omitted] •Hydroxypropyl methylcellulose - copper nanoparticles were prepared chemically.•Spherical nanoparticles were achieved with an average size of ∼38 ± 2 nm.•The nanocomposite hydrogels were fabricated via solution casting technique.•Antibacterial activity depended on the amounts of nanoparticles in hydrogel. Currently, special emphasis is being given to the design and fabrication of antibacterial nanocomposite hydrogels for wound dressing applications. Herein, we report the synthesis and characterization of hydroxypropyl methylcellulose (HPMC) reinforced with HPMC capped copper nanoparticles (HCu NPs) based nanocomposite hydrogel films (NHFs). Spherical nanostructures of HCu NPs (∼40 nm) were achieved by facile precipitation technique using ascorbic acid as a nucleating agent and subsequently made their NHFs via solution casting method. Spectral, thermal and structural characteristics of the developed materials were carried out. Antibacterial activity of the resultant NHFs showed the MIC and MBC values of 350 and 1400 μg/mL for S. aureus, and 500 and 2000 μg/mL for E. coli, respectively. These results conveyed that the HCu NPs incorporated HPMC NHFs can be used effectively in antibacterial applications.