Antitumor Components from an Actinomycete Strain 6011W

Three bioactive compounds that inhibited nucleoside transport were isolated from the cultured broth of Streptoverticillium sp. 6011W. The structures of those compounds were characterized as cinnamamide, N-(tetrahydro-2-oxo-3-thienyl)-acetamide and benzamide, respectively. They all inhibited radiolab...

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Published inJournal of asian natural products research Vol. 2; no. 1; pp. 31 - 38
Main Authors Jiang, Xiao-Feng, Shang, Bo-Yang, Jin, Lian-Fang, Hu, Ji-Lan, Zhen, Yong-Su
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.01.1999
Subjects
Actinomycetales - chemistry
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Antitumor agent
Cinnamamide
Drug Screening Assays, Antitumor
Humans
Mice
Molecular Structure
Nucleoside transport inhibitor
Spectrum Analysis
Tumor Cells, Cultured
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Summary:Three bioactive compounds that inhibited nucleoside transport were isolated from the cultured broth of Streptoverticillium sp. 6011W. The structures of those compounds were characterized as cinnamamide, N-(tetrahydro-2-oxo-3-thienyl)-acetamide and benzamide, respectively. They all inhibited radiolabeled thymidine transport into Ehrlich carcinoma cells, with IC 50 values of 30.4, 97.2 and 85.4 μM, respectively. When administered i.p., cinnamamide not only inhibited the growth of transplanted tumors but also reduced the number of lung metastases in mice bearing Lewis lung carcinoma. The results suggest that nucleoside transport inhibition assay is a valuable model to search for antitumor agents of natural origin.
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ISSN:1028-6020
1477-2213
DOI:10.1080/10286029908039888