Pancreatic Islet α Cell Commands Itself: Secrete More Glucagon

Glucagon release by pancreatic α cells is stimulated by low glucose through unclear mechanisms. In this issue of Cell Metabolism, Cabrera et al. (2008) show that glutamate released from α cells acts on glutamate receptors in a positive autocrine fashion that drives glucagon secretion during small ph...

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Bibliographic Details
Published inCell metabolism Vol. 7; no. 6; pp. 474 - 475
Main Authors Gaisano, Herbert Y., Leung, Yuk M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2008
Subjects
Autocrine Communication
Blood Glucose
Glucagon - secretion
Glucagon-Secreting Cells - physiology
Glucagon-Secreting Cells - secretion
Glutamic Acid
Humans
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Summary:Glucagon release by pancreatic α cells is stimulated by low glucose through unclear mechanisms. In this issue of Cell Metabolism, Cabrera et al. (2008) show that glutamate released from α cells acts on glutamate receptors in a positive autocrine fashion that drives glucagon secretion during small physiological fluctuations of blood glucose.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-2
ObjectType-Feature-4
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ObjectType-Review-1
ObjectType-Article-3
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2008.05.003