A double-network polysaccharide-based composite hydrogel for skin wound healing

• Published in: Carbohydrate polymers Vol. 261; p. 117870
• Main Authors: He, Yuxin, Li, Yang, Sun, Yadong, Zhao, Shijia, Feng, Miao, Xu, Guoming, Zhu, Haofang, Ji, Peihong, Mao, Hongli, He, Yiyan, Gu, Zhongwei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2021
• Subjects: Alginates - chemical synthesis; Alginates - chemistry; Alginates - therapeutic use; angiogenesis; animal models; Animals; bandages; Bandages, Hydrocolloid; biocompatibility; Carboxymethyl chitosan; Cells, Cultured; chitosan; Chitosan - analogs & derivatives; Chitosan - chemical synthesis; Chitosan - chemistry; Chitosan - therapeutic use; collagen; Collagen - chemical synthesis; Collagen - chemistry; Collagen - pharmacokinetics; Collagen - therapeutic use; Collagen peptide; composite polymers; Double-network hydrogel; Humans; hydrogels; Hydrogels - chemical synthesis; Hydrogels - chemistry; Hydrogels - therapeutic use; Materials Testing; mechanical properties; Mice; Oxidized methacrylate sodium alginate; Peptide Fragments - chemical synthesis; Peptide Fragments - chemistry; Peptide Fragments - pharmacokinetics; Peptide Fragments - therapeutic use; Polysaccharides - chemistry; Polysaccharides - therapeutic use; skin (animal); Skin - drug effects; Skin - injuries; Skin - pathology; sodium alginate; swelling (materials); tissue repair; Wound dressing; Wound Healing - drug effects; wound treatment; Wound dressing; Collagen peptide; Double-network hydrogel; Carboxymethyl chitosan; Oxidized methacrylate sodium alginate
• ISSN: 0144-8617; 1879-1344; 1879-1344
• DOI: 10.1016/j.carbpol.2021.117870

[Display omitted] •A double-network polysaccharide-based composite hydrogel was developed.•Mechanical properties of the hydrogel were enhanced by grafted methacrylate groups.•The hydrogel functionalized with collagen peptide promoted cell proliferation and wound healing. Effective wound dressings are of great significance in preventing infections and promoting wound healing. However, most existing hydrogel dressings have an inadequacy in either mechanical performance, biological activities, or versatilities. Here we presented a double-network cross-linked polysaccharide-based hydrogel composed of collagen peptide-functionalized carboxymethyl chitosan (CS) and oxidized methacrylate sodium alginate (SA). The hydrogel possessed interconnected porous morphologies, suitable swelling ratios, excellent mechanical properties, and favorable biocompatibility. Meanwhile, the in vivo studies using a mouse full-thickness skin defect model showed that the double-network CS/SA hydrogel significantly accelerated wound healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization. Therefore, the functionalized double-network hydrogel should be a potential candidate as wound dressings