Drug Resistance in Hepatocellular Carcinoma: Theoretical Basis and Therapeutic Aspects

Primary liver cancer is one of the most common malignant tumors with high mortality and increasing incidence worldwide. Currently, chemotherapy is an important comprehensive treatment for moderate or advanced liver cancer. Despite the effective therapeutic effects initially achieved by chemotherapy,...

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Published inFrontiers in bioscience (Landmark. Print) Vol. 29; no. 2; p. 52
Main Authors Lei, Ya-Ruo, He, Xian-Lu, Li, Jun, Mo, Chun-Fen
Format Journal Article
LanguageEnglish
Published Singapore IMR Press 04.02.2024
Subjects
Apoptosis - genetics
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
chemotherapy
Drug Resistance, Multiple - genetics
Drug Resistance, Neoplasm - genetics
hepatocellular carcinoma
Humans
immunotherapy
Liver Neoplasms - drug therapy
Liver Neoplasms - genetics
Liver Neoplasms - pathology
multidrug resistance
targeted therapy
tumor microenvironment
Tumor Microenvironment - genetics
multidrug resistance
targeted therapy
tumor microenvironment
chemotherapy
hepatocellular carcinoma
immunotherapy
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Summary:Primary liver cancer is one of the most common malignant tumors with high mortality and increasing incidence worldwide. Currently, chemotherapy is an important comprehensive treatment for moderate or advanced liver cancer. Despite the effective therapeutic effects initially achieved by chemotherapy, the high phenotypic and molecular heterogeneity of liver cancer cells facilitates resistance to conventional chemotherapy or targeted therapy and even leads to multidrug resistance (MDR), which is one of the major obstacles for clinical chemotherapy. Drug resistance exhibits multiple and complex molecular mechanisms to antagonize therapy under pharmacological pressure, including overexpression of drug efflux transporters, downstream adaptive response (such as apoptosis, autophagy, and endoplasmic reticulum stress), dysfunction of DNA damage repair (DDR), epigenetic modification, tumor microenvironment (TME) as well as extracellular matrix (ECM). In this paper, we summarize the recent research progress and intervention strategies for drug resistance in hepatocellular carcinoma (HCC), which will provide a promising therapeutic strategy for overcoming MDR in liver cancer.
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ISSN:2768-6701
2768-6698
DOI:10.31083/j.fbl2902052