Interventional radiotherapy (brachytherapy) for squamous cell carcinoma of the nasal vestibule: a multidisciplinary systematic review

• Published in: EJD. European journal of dermatology Vol. 29; no. 4; pp. 417 - 421
• Main Authors: Tagliaferri, Luca, Fionda, Bruno, Bussu, Francesco, Parrilla, Claudio, Lancellotta, Valentina, Deodato, Francesco, Cammelli, Silvia, Boldrini, Luca, Gambacorta, Maria Aantonietta, Morganti, Alessio Giuseppe, Valentini, Vincenzo, Paludetti, Gaetano, Peris, Ketty, Kovacs, György
• Format: Journal Article
• Language: English
• Published: Paris John Libbey Eurotext 01.08.2019
• Subjects: Brachytherapy - adverse effects; Brachytherapy - methods; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Cause of Death; Dermatology; Disease-Free Survival; Female; Germany; Humans; Italy; Male; Medicine; Medicine & Public Health; Nasal Cavity - pathology; Nasal Cavity - radiation effects; Neoplasm Invasiveness - pathology; Neoplasm Staging; Nose Neoplasms - mortality; Nose Neoplasms - pathology; Nose Neoplasms - radiotherapy; Prognosis; Radiotherapy Dosage; Risk Assessment; Survival Analysis; Therapy; Treatment Outcome; Italy; Germany; multidisciplinary; nasal vestibule; interventional radiotherapy; squamous cell carcinoma
• ISSN: 1167-1122; 1952-4013
• DOI: 10.1684/ejd.2019.3599

Background Surgery is the first-line therapy for treatment of cutaneous squamous cell carcinoma (cSCC), and interventional radiotherapy is recommended when surgery is not feasible, contraindicated, or refused by the patient. Objectives To provide a multidisciplinary systematic review of the role of interventional radiotherapy for the treatment of cSCC of the nasal vestibule. Materials and Methods A systematic search was performed; primary outcomes were tumour local control and overall survival. Acute toxicity, late toxicity, and functional cosmetic results, regardless of the scoring systems used, were secondary outcomes. Results After full-text reviewof the 92 papers initially identified, we included only 10 papers in the review; no randomized controlled trials or prospective studies were identified. Five studies reported five-year local control, with rates ranging between 69% and 97%. A high level of heterogeneity was observed regarding the methods used to assess treatment-related toxicity. Conclusion Interventional radiotherapy may be considered for lesions specifically arising from the area of the nasal vestibule. A multidisciplinary approach might help to select cases that are potential candidates for conservative treatment according to the tumour and the patient’s features.