Elevated Levels of CTRP1 in Obesity Contribute to Tumor Progression in a p53-Dependent Manner

Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor...

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Published inCancers Vol. 13; no. 14; p. 3619
Main Authors Park, Rackhyun, Jang, Minsu, Park, Yea-In, Park, Yeonjeong, Namkoong, Sim, Lee, Jin I., Park, Junsoo
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 19.07.2021
MDPI
Subjects
Adipocytes
Adiponectin
Antibodies
Cancer
Cell culture
Cell cycle
Cell growth
Cell migration
Diet
High fat diet
Lung cancer
Molecular modelling
Obesity
p53 Protein
Proteins
Risk factors
Transcription
Tumor necrosis factor
Tumor necrosis factor-TNF
Tumor suppressor genes
St Louis Missouri
United States > US
Sweden
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Summary:Mounting evidence supports the relationship between obesity and cancer. However, the molecular mechanisms linking obesity with cancer remain largely uninvestigated. In this study, we demonstrate that the expression of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralogue, contributes to tumor growth by regulating the tumor suppressor p53. In our study, obese mice on a high-fat diet showed higher serum CTRP1 levels. Through in vitro experiments, we showed that the secreted form of CTRP1 in the culture medium decreased p53 expression and p53-dependent transcription in the cells. Moreover, CTRP1 treatment enhanced colony formation and cell migration. These results collectively suggest that elevated levels of CTRP1 in obesity significantly contribute to tumor progression.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13143619