Long-term retention of injected aluminium-26

Data previously reported on the whole-body retention of aluminium-26 (26Al) in a male volunteer are extended to 8 years after intravenous administration as citrate, when only ~2% of the injected tracer remained. The extended data, combined with a report elsewhere of the late urinary and faecal excre...

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Bibliographic Details
Published inHuman & experimental toxicology Vol. 31; no. 12; pp. 1195 - 1198
Main Authors Newton, D, Talbot, RJ
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.12.2012
Sage Publications Ltd
Subjects
Adult
Aluminum
Body Burden
Citric Acid - metabolism
Citric Acid - pharmacokinetics
Feces
Half-Life
Humans
Injections, Intravenous
Male
Radiation Dosage
Radioisotopes - metabolism
Radioisotopes - pharmacokinetics
Time Factors
toxicology
aluminium
excretion
transdermal
accumulation
retention
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Summary:Data previously reported on the whole-body retention of aluminium-26 (26Al) in a male volunteer are extended to 8 years after intravenous administration as citrate, when only ~2% of the injected tracer remained. The extended data, combined with a report elsewhere of the late urinary and faecal excretion of 26Al by this subject, reinforce indications that transdermal losses contribute to the clearance of systemic aluminium and mitigate its long-term accumulation from chronic exposure.
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ISSN:0960-3271
1477-0903
DOI:10.1177/0960327112441038