Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation

Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain developme...

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Published inToxicological sciences Vol. 165; no. 1; pp. 14 - 20
Main Authors Fritsche, Ellen, Barenys, Marta, Klose, Jördis, Masjosthusmann, Stefan, Nimtz, Laura, Schmuck, Martin, Wuttke, Saskia, Tigges, Julia
Format Journal Article
LanguageEnglish
Published United States 01.09.2018
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Summary:Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain development can be disassembled into several neurodevelopmental endpoints which can be represented by a combination of different alternative assays. In this review article, we provide a scientific rationale for the neurodevelopmental endpoints that are currently chosen to establish assays with human stem/and progenitor cells. Assays covering these major neurodevelopmental endpoints are thought to assemble as building blocks of a DNT testing battery.
ISSN:1096-6080
1096-0929
DOI:10.1093/toxsci/kfy175