Development of bioactive compounds-loaded chitosan films by using a QbD approach – A novel and potential wound dressing material

• Published in: Reactive & functional polymers Vol. 138; pp. 46 - 54
• Main Authors: Colobatiu, Liora, Gavan, Alexandru, Mocan, Andrei, Bogdan, Catalina, Mirel, Simona, Tomuta, Ioan
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.2019; Elsevier BV
• Subjects: Acceleration; Biological activity; Chitosan; Design space; Film dressing; Film thickness; Optimization; Polyethylene glycol; Polymer films; Polymers; Polyvinyl alcohol; Quality by design; Risk analysis; Risk assessment; Wound healing; Design space; Film dressing; Chitosan; Risk analysis; Quality by design

In the present study, a Quality by Design (QbD) approach was applied in order to develop and optimize a chitosan film formulation loaded with bioactive compounds, intended for further use as an aid in the acceleration of wound healing. Chitosan was chosen as film forming polymer, polyethylene glycol...