Development of bioactive compounds-loaded chitosan films by using a QbD approach – A novel and potential wound dressing material

In the present study, a Quality by Design (QbD) approach was applied in order to develop and optimize a chitosan film formulation loaded with bioactive compounds, intended for further use as an aid in the acceleration of wound healing. Chitosan was chosen as film forming polymer, polyethylene glycol...

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Bibliographic Details
Published inReactive & functional polymers Vol. 138; pp. 46 - 54
Main Authors Colobatiu, Liora, Gavan, Alexandru, Mocan, Andrei, Bogdan, Catalina, Mirel, Simona, Tomuta, Ioan
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.05.2019
Elsevier BV
Subjects
Acceleration
Biological activity
Chitosan
Design space
Film dressing
Film thickness
Optimization
Polyethylene glycol
Polymer films
Polymers
Polyvinyl alcohol
Quality by design
Risk analysis
Risk assessment
Wound healing
Design space
Film dressing
Chitosan
Risk analysis
Quality by design
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Summary:In the present study, a Quality by Design (QbD) approach was applied in order to develop and optimize a chitosan film formulation loaded with bioactive compounds, intended for further use as an aid in the acceleration of wound healing. Chitosan was chosen as film forming polymer, polyethylene glycol was used as plasticizer, while polyvinyl alcohol was added to improve the bioadhesive properties of the films. Risk assessment strategy was applied to identify the critical formulation variables, which were further introduced as factors of a 3 level Box Behnken design of experiments. The optimal film formulation registered a film thickness of 0.09 mm, solubility in water of 44.9% and a high swelling degree of 2157.4%. The optimized formulation, as well as a placebo formulation without bioactive compounds proved to have a good antibacterial activity. We conclude that in the current study, the QbD approach was successfully applied in order to ensure a good understanding of the manufacturing process, as well as to optimize the formulation of chitosan films. To the best of our knowledge, this is the first time when a QbD approach has been applied in order to develop and optimize a film formulation as a novel wound dressing material.
ISSN:1381-5148
1873-166X
DOI:10.1016/j.reactfunctpolym.2019.02.013