Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents
Nine novel AMinoalkoxy substituted benzo[b]xanthones (3a–i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines, including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE, by the MTT (2-(4,5-dimethyl-thiazol-2-yl)-3,5-diphenyl-2H-tetrazolium bromide) method. The...
Saved in:
| Published in | Journal of the Serbian Chemical Society Vol. 78; no. 9; pp. 1301 - 1308 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Belgrade
Journal of the Serbian Chemical Society
01.01.2013
Serbian Chemical Society |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Nine novel AMinoalkoxy substituted benzo[b]xanthones (3a–i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines, including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE, by the MTT (2-(4,5-dimethyl-thiazol-2-yl)-3,5-diphenyl-2H-tetrazolium bromide) method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, AMong them compounds 3a and 3h showed higher antitumor activity than the other tested compounds against most cell lines. The influences of two kinds of structural factors, i.e., the terminal AMino group and length of the carbon spacers, on the anticancer activities were explored to discuss preliminary structure–activity relationships. |
|---|---|
| AbstractList | Nine novel AMinoalkoxy substituted benzo[b]xanthones (3a–i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines, including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE, by the MTT (2-(4,5-dimethyl-thiazol-2-yl)-3,5-diphenyl-2H-tetrazolium bromide) method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, AMong them compounds 3a and 3h showed higher antitumor activity than the other tested compounds against most cell lines. The influences of two kinds of structural factors, i.e., the terminal AMino group and length of the carbon spacers, on the anticancer activities were explored to discuss preliminary structure–activity relationships. Nine novel aminoalkoxy substituted benzoxanthones (3a-3i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE by MTT method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, among them compounds 3a and 3h showed higher antitumor activity than other tested compounds against most cell lines. The influence of two kinds of structural factors including the terminal amino group and length of carbon spacers on the anticancer activities were explored to discuss the preliminary structure-activity relationships. Nine novel aminoalkoxy substituted benzoxanthones (3a-3i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE by MTT method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, among them compounds 3a and 3h showed higher antitumor activity than other tested compounds against most cell lines. The influence of two kinds of structural factors including the terminal amino group and length of carbon spacers on the anticancer activities were explored to discuss the preliminary structure-activity relationships. nema |
| Author | Zhi-Kai Daiand Shi-Hua Gao Luo, Lin Jiang-Ke, Qin |
| Author_xml | – sequence: 1 givenname: Lin surname: Luo fullname: Luo, Lin – sequence: 2 givenname: Qin surname: Jiang-Ke fullname: Jiang-Ke, Qin – sequence: 3 fullname: Zhi-Kai Daiand Shi-Hua Gao |
| BookMark | eNqNkc1rGzEUxEVJoU7aY--CnLfVx-rrGEzTJBhySG6hCK301pXZSK60NnH_-qpxCOSW04PhNzMP5hSdpJwAoa-UfGPM6O83d0vKiGGCSLL6gBZUM9KpntETtCBcsE5Qbj6h01o3hDAheL9A67tDmn9DjRW7FPAQ85TX0bsJw95NOzfHnHAeccp7mPAA6W9-GH49uWZq5ThAifsG7aH5K97mGdIcm7sBcd495oLdukn1M_o4uqnCl5d7hu4vf9wvr7rV7c_r5cWq89zouXOcUKm0FgwYEVIITUgA4AaCIkGZID1IFvg4KMp7LUejaTCeqYH3EhQ_Q9fH2JDdxm5LfHTlYLOL9lnIZW1dmaOfwEozeOYH4YH4Huig1eiFDCr0TNDAdcs6P2ZtS_6zgzrbTd6V1L631EjG-1bJ30ER1TeqO1K-5FoLjK-_UWL_j2ffjMf_AcdQjmk |
| CitedBy_id | crossref_primary_10_3390_ph14111144 crossref_primary_10_1016_j_ejmech_2014_07_076 crossref_primary_10_3390_molecules27061970 crossref_primary_10_1016_j_ejmech_2016_03_058 crossref_primary_10_2174_1568026622666220901145002 crossref_primary_10_1039_D0QO00659A crossref_primary_10_14233_ajchem_2020_22503 crossref_primary_10_2174_1573406419666221226093311 |
| ContentType | Journal Article |
| Copyright | Copyright Journal of the Serbian Chemical Society 2013 |
| Copyright_xml | – notice: Copyright Journal of the Serbian Chemical Society 2013 |
| DBID | AAYXX CITATION 8FE 8FG ABJCF ABUWG AFKRA AZQEC BENPR BGLVJ CCPQU D1I DWQXO HCIFZ KB. PDBOC PIMPY PQEST PQQKQ PQUKI PRINS DOA |
| DOI | 10.2298/JSC120925060L |
| DatabaseName | CrossRef ProQuest SciTech Collection ProQuest Technology Collection Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials AUTh Library subscriptions: ProQuest Central Technology Collection ProQuest One Community College ProQuest Materials Science Collection ProQuest Central SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Materials Science Database Materials Science Collection Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Materials Science Collection Technology Collection ProQuest Central Essentials ProQuest One Academic Eastern Edition Materials Science Collection ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Technology Collection ProQuest SciTech Collection ProQuest Central China ProQuest Central ProQuest One Academic UKI Edition ProQuest Central Korea Materials Science & Engineering Collection Materials Science Database ProQuest One Academic |
| DatabaseTitleList | Publicly Available Content Database Publicly Available Content Database CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1820-7421 |
| EndPage | 1308 |
| ExternalDocumentID | oai_doaj_org_article_69bc2cb5ce0c4e1b87fc56d7d4251d38 10_2298_JSC120925060L |
| GroupedDBID | 29L 2WC 53G 53S 5GY 8FE 8FG A8Z AAFWJ AAYXX ABDBF ABJCF ACGFO ACIWK ADBBV AEGXH AENEX AFKRA AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS BCNDV BENPR BGLVJ C1A CCPQU CITATION CS3 D1I DU5 E3Z EBS EJD EN8 EOJEC ESTFP ESX GROUPED_DOAJ GX1 HCIFZ HH5 IPNFZ KB. KQ8 ML- M~E OBODZ OK1 P2P PDBOC PIMPY PROAC RIG RNS TR2 TUS XSB ~8M ABUWG AZQEC DWQXO PQEST PQQKQ PQUKI PRINS |
| ID | FETCH-LOGICAL-c398t-a301678852e205655800dee39ed70d79d6ce62d3fb713486f981d9c27b346e73 |
| IEDL.DBID | 8FG |
| ISSN | 0352-5139 |
| IngestDate | Tue Oct 22 15:16:05 EDT 2024 Thu Oct 10 18:02:51 EDT 2024 Thu Oct 10 17:55:48 EDT 2024 Fri Aug 23 04:02:46 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c398t-a301678852e205655800dee39ed70d79d6ce62d3fb713486f981d9c27b346e73 |
| OpenAccessLink | https://www.proquest.com/docview/1962343463?pq-origsite=%requestingapplication% |
| PQID | 1962343074 |
| PQPubID | 2046308 |
| PageCount | 8 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_69bc2cb5ce0c4e1b87fc56d7d4251d38 proquest_journals_1962343463 proquest_journals_1962343074 crossref_primary_10_2298_JSC120925060L |
| PublicationCentury | 2000 |
| PublicationDate | 2013-00-00 20130101 2013-01-01 |
| PublicationDateYYYYMMDD | 2013-01-01 |
| PublicationDate_xml | – month: 01 year: 2013 text: 20130101 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Belgrade |
| PublicationPlace_xml | – name: Belgrade |
| PublicationTitle | Journal of the Serbian Chemical Society |
| PublicationYear | 2013 |
| Publisher | Journal of the Serbian Chemical Society Serbian Chemical Society |
| Publisher_xml | – name: Journal of the Serbian Chemical Society – name: Serbian Chemical Society |
| SSID | ssj0025534 |
| Score | 2.0350254 |
| Snippet | Nine novel aminoalkoxy substituted benzoxanthones (3a-3i) were synthesized.
Their antitumor activities were evaluated in five human solid tumor cell
lines... Nine novel AMinoalkoxy substituted benzo[b]xanthones (3a–i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines,... Nine novel aminoalkoxy substituted benzoxanthones (3a-3i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines... |
| SourceID | doaj proquest crossref |
| SourceType | Open Website Aggregation Database |
| StartPage | 1301 |
| SubjectTerms | Anticancer properties benzoxanthone Biotechnology in vitro anticancer activity xanthone |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrZ3fS8MwEMeD-KIv4k-cTsmD-Fa2JU3aPOpwjKG-bMJApDTJVQRtx7oN9a_3knbqEPTF17aBcHfNfa_0PkfImTRhpnjIA5YJFTg-SRBrzgIOoNsWc671MyNvbmX_LhyMxfjbqC_3T1iFB64M15JKG2a0MNA2IXR0HGVGSBtZDLaO5VWbb1sti6m61BKCV-AogaUWipyKrsmYiluDYdf1izJH1rteyUYe2v_jTPaJprdNtmqFSC-qne2QNch3yUZ3OZhtjzwO33KUbeVTSdPc0gqj5GxNv9DdtMhoXizgmWrI34t7_fCaekwAUIsxt_C4b1xf0kkxcz8M4erUdezOX4opTV2_VblPRr2rUbcf1PMSAsNVPAtS7noK4lgwYKhrhEAxaAG4Ahu1baSsNCCZ5Zl2DaSxzBSKVWVYpHkoIeIHZD3HfRwSyiVYq5jVRqkw65jYY-uBCa0x3StokPOl2ZJJRcVIsJpw9k1W7Nsgl86onw85mLW_gC5Oahcnf7m4QZpLlyT1G1YmeHIwjDFUQL_dDiU_-o8tHJNN5udguG8vTbI-m87hBNXITJ_6wPsALQDcWw priority: 102 providerName: Directory of Open Access Journals |
| Title | Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents |
| URI | https://www.proquest.com/docview/1962343074 https://www.proquest.com/docview/1962343463 https://doaj.org/article/69bc2cb5ce0c4e1b87fc56d7d4251d38 |
| Volume | 78 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fSxwxEA7-eKgvpdWK1-qRB-nb4l2yySZP4p1eRaoUtSCILJtkVgTdPW9PafvXdya7Z5GCTwubzbJMJjPfzGa-YWxX-7S0MpWJKJVNiJ8kMU6KRAK4QUCfG2LPyNMzffwzPblSV13CremOVS5sYjTUofaUI99DTRH4zlTL_eljQl2j6O9q10Jjma0ORZZR8GUm314CLqVkSx-lMOBCqNNybAphzd7JxZiqRgXx631_5ZMidf9_ljm6m8kH9r7DifygXdiPbAmqdfZuvGjPtsFuL35XCN6au4YXVeAtmRJJnP8j8OZ1yav6Ge65g-pPfe1ufhWRLAB4QM17jqTfOL_h03pOx4ZwdkF1u08P9YwXVHXVfGKXk6PL8XHSdU1IvLRmnhSSKguMUQIEohulEBIGAGkhZIOQ2aA9aBFk6aiM1OjSImS1XmQOhQuZ3GQrFX7HFuNSQwhWBOetTcuhN5G8HoRyDp2-hR77uhBbPm25MXKMKUi--Sv59tiIhPryEFFaxxv17DbvdkiurfPCO-Vh4FMYOpOVXumQBbQqwyBNj20vliTv9lmTd1qBOOitYVSaz28Pf2FrIva5oNzKNluZz55gB9HG3PWjSvXZ6sHocDTB6-jo7Md5P8bufwF6btb_ |
| link.rule.ids | 315,783,787,867,2109,4031,12777,21400,27935,27936,27937,33385,33756,43612,43817 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1RT9swELZG9wAv0zZAdLDND4i3iNaOHftp2qp1HSu8UCQkhKLYviCkLSlNqbb9-t05KQhN4jWOo-h8vvvu7PuOsUPt09LKVCaiVDYhfpLEOCkSCeAGAX1uiD0jT8_05CI9uVSXXcKt6a5Vrm1iNNSh9pQjP0ZNEfjNVMtP87uEukbR6WrXQmODvUwl-mqqFB9_ewi4lJItfZTCgAuhTsuxKYQ1xyfnI6oaFcSvN33ikyJ1_3-WObqb8Wv2qsOJ_HO7sG_YC6jess3Ruj3bNrs5_1MheGtuG15UgbdkSiRx_kjgzeuSV_UKfnIH1d_6yl3_LiJZAPCAmreKpN84v-HzeknXhnB2QXW797_qBS-o6qrZYbPx19loknRdExIvrVkmhaTKAmOUAIHoRimEhAFAWgjZIGQ2aA9aBFk6KiM1urQIWa0XmUPhQiZ3Wa_C_9hjXGoIwYrgvLVpOfQmkteDUM6h07fQZ0drseXzlhsjx5iC5Js_kW-ffSGhPrxElNbxQb24ybsdkmvrvPBOeRj4FIbOZKVXOmQBrcowSNNnB-slybt91uSdViAOem4Ylebd88Mf2eZkdjrNp9_PfuyzLRF7XlCe5YD1lot7eI_IY-k-RPX6ByCr1eA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+and+biological+evaluation+of+novel+benzo%5Bb%5Dxanthone+derivatives+as+potential+antitumor+agents&rft.jtitle=Journal+of+the+Serbian+Chemical+Society&rft.au=Luo%2C+Lin&rft.au=Qin%2C+Jiang-Ke&rft.au=Dai%2C+Zhi-Kai&rft.au=Gao%2C+Shi-Hua&rft.date=2013&rft.issn=0352-5139&rft.eissn=1820-7421&rft.volume=78&rft.issue=9&rft.spage=1301&rft.epage=1308&rft_id=info:doi/10.2298%2FJSC120925060L&rft.externalDBID=n%2Fa&rft.externalDocID=10_2298_JSC120925060L |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0352-5139&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0352-5139&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0352-5139&client=summon |