Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents

Nine novel AMinoalkoxy substituted benzo[b]xanthones (3a–i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines, including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE, by the MTT (2-(4,5-dimethyl-thiazol-2-yl)-3,5-diphenyl-2H-tetrazolium bromide) method. The...

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Bibliographic Details
Published inJournal of the Serbian Chemical Society Vol. 78; no. 9; pp. 1301 - 1308
Main Authors Luo, Lin, Jiang-Ke, Qin, Zhi-Kai Daiand Shi-Hua Gao
Format Journal Article
LanguageEnglish
Published Belgrade Journal of the Serbian Chemical Society 01.01.2013
Serbian Chemical Society
Subjects
Anticancer properties
benzoxanthone
Biotechnology
in vitro anticancer activity
xanthone
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Summary:Nine novel AMinoalkoxy substituted benzo[b]xanthones (3a–i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines, including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE, by the MTT (2-(4,5-dimethyl-thiazol-2-yl)-3,5-diphenyl-2H-tetrazolium bromide) method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, AMong them compounds 3a and 3h showed higher antitumor activity than the other tested compounds against most cell lines. The influences of two kinds of structural factors, i.e., the terminal AMino group and length of the carbon spacers, on the anticancer activities were explored to discuss preliminary structure–activity relationships.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC120925060L