Lymphoepithelial carcinoma of the larynx: an extremely rare tumour in a patient of Chinese descent

Lymphoepithelial carcinoma (LEC) of the larynx is an extremely rare tumour which, unlike its nasopharyngeal counterpart, has shown a propensity to affect elderly Caucasian men and is not commonly associated with Epstein-Barr virus. We present a 70-year-old Chinese man who complained of hoarseness an...

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Published inBMJ case reports Vol. 14; no. 10; p. e245945
Main Authors Yap, Jiawei Alexander, Bundele, Manish M, Lim, Ming Yann, Goh, Julian Park Nam
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group LTD 20.10.2021
BMJ Publishing Group
Subjects
Airway management
Biopsy
Cancer
Cartilage
Case Report
Case reports
Dysphagia
Epstein-Barr virus
Exocrine glands
Head & neck cancer
Laryngeal cancer
Larynx
Ostomy
Thyroid gland
Tumors
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Summary:Lymphoepithelial carcinoma (LEC) of the larynx is an extremely rare tumour which, unlike its nasopharyngeal counterpart, has shown a propensity to affect elderly Caucasian men and is not commonly associated with Epstein-Barr virus. We present a 70-year-old Chinese man who complained of hoarseness and dysphagia. Nasoendoscopy revealed a left supraglottic tumour. Preoperative MRI (in particular Diffusion Weighted Imaging) showed the possibility of two distinct components within a tumour. The patient underwent total pharyngolaryngectomy and bilateral selective neck dissection. The final histology report confirmed the presence of a tumour with two distinct components: predominant LEC with a smaller conventional (keratinising) squamous cell carcinoma component. The patient recovered well after surgery and subsequently underwent adjuvant radiotherapy. Final staging was pT3 N2c M0 (AJCC stage IVA). Follow-up over 2 years revealed no tumour recurrence.
Bibliography:ObjectType-Case Study-2
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ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2021-245945