A target-triggered fluorescence-SERS dual-signal nano-system for real-time imaging of intracellular telomerase activity

• Published in: Talanta (Oxford) Vol. 269; p. 125469
• Main Authors: Zhao, Yu-Jie, Shen, Ping-Fan, Fu, Jing-Hao, Yang, Feng-Rui, Chen, Zeng-Ping, Yu, Ru-Qin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2024
• Subjects: biocompatibility; biomarkers; biomedical research; DNA; Dual-signal nano-system; Fluorescence; Live-cell imaging; nanomaterials; photobleaching; prognosis; rhodamines; SERS; telomerase; Telomerase activity; therapeutics; Fluorescence; Live-cell imaging; Dual-signal nano-system; SERS; Telomerase activity

Telomerase (TE) is a promising diagnostic and prognostic biomarker for many cancers. Quantification of TE activity in living cells is of great significance in biomedical and clinical research. Conventional fluorescence-based sensors for quantification of intracellular TE may suffer from problems of...