A pilot study assessing tolerance safety and feasibility of diagnostic transnasal esophagogastroduodenoscopy using an improved larger caliber endoscope and an adapted topical anesthesia

• Published in: Surgical endoscopy Vol. 29; no. 10; pp. 3002 - 3009
• Main Authors: Balassone, Valerio, Dauri, Mario, Cappuccio, Roberto, Di Camillo, Mauro, Benavoli, Domenico, Buonomo, Oreste, Petrella, Giuseppe, Stroppa, Italo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2015; Springer Nature B.V
• Subjects: Abdominal Surgery; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthetics, Local - administration & dosage; Cost control; Dynamic Manuscript; Endoscopes; Endoscopy; Endoscopy, Digestive System - methods; European literature; Feasibility Studies; Female; Gastroenterology; Gynecology; Hepatology; Humans; Imidazoles - administration & dosage; Intubation; Lidocaine - administration & dosage; Male; Medicine; Medicine & Public Health; Middle Aged; Nasal Cavity; Nebulizers and Vaporizers; Ostomy; Patient Satisfaction; Patients; Pilot Projects; Proctology; Prospective Studies; Surgery; Visual Analog Scale; Rome Italy; Italy; Feasibility; Endoscopy; Safety; Patient compliance; Nose
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-014-4025-5

Background Transnasal esophagogastroduodenoscopy (TN-EGDS) is well tolerated by patients and the examination is perceived comfortable without the need of a sedative drug. Conversely, mainly in Western literature, some authors report limitations in illumination, image quality, and working channel as affecting TN-EGDS diffusion. To overcome these disadvantages, a new transnasal endoscope (TNE) was tested but, due to its larger diameter, we have no evidence of its clinical safety and tolerability. A new adapted nasal anesthesia could be useful to improve TNE tolerance. In an independent, not sponsored, pilot prospective study we enrolled, in a busy clinical hospital setting, 30 adult patients receiving nasal atomized Lidocaine and Xylometazoline (XAL) to undergo a diagnostic TN-EGDS with TNE to evaluate its tolerance, safety, and feasibility. Methods Three physicians enrolled inpatients and outpatients with indication to diagnostic EGDS during a 6-month period. Main outcome measures were cardio-pulmonary monitoring data and patients’ answers to an adapted questionnaire investigating pain, anxiety level, willingness to repeat the examination, operators’ scores about endoscopy quality, examination conduction and anesthesia-related complications. Results The examination was completed by the transnasal route in 100 % of the enrolled patients, endoscopy satisfaction and feasibility were scored to nearly the highest levels by the three different physicians. A total of 29/30 patients (96.6 %) declared the willingness to repeat the same examination if needed. The mean patients’ score for overall pain was 3.7 ± 1 SD (range 1–10 by Visual Analog Scale). Mean endoscopy duration was 11.1 ± 2.6 min (range 5.0–19.0). In a total of 17/30 TN-EGDS that lasted more than 11 min, higher heart frequency variations and worse tolerance scores were found ( p  < 0.05). Conclusion Our pilot study demonstrates that TN-EGDS with TNE and NA is safe, well tolerated, and feasible. The best clinical tolerance is reached when TN-EGDS lasts <11 min.