The Role of Ferroptosis in Nervous System Disorders

Ferroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation whi...

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Bibliographic Details
Published inJournal of integrative neuroscience Vol. 22; no. 1; p. 19
Main Authors Du, Lixia, Wu, You, Fan, Zhongmin, Li, Yi, Guo, Xiaofeng, Fang, Zongping, Zhang, Xijing
Format Journal Article
LanguageEnglish
Published Singapore IMR Press 16.01.2023
Subjects
Apoptosis
Ferroptosis
glutathione
Humans
Iron
lipid peroxidation
nervous system disorders
Neurodegenerative Diseases
Stroke
iron
ferroptosis
lipid peroxidation
nervous system disorders
glutathione
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Summary:Ferroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain injury, and sepsis-associated encephalopathy. This review summarizes the pathogenesis of ferroptosis and its relationship with various nervous system disorders.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0219-6352
DOI:10.31083/j.jin2201019