Self-assembled polylactic acid (PLA): Synthesis, properties and biomedical applications

The surface morphology and topography of cell culture substrates play an important role in cell proliferation and growth. Regulation of the surface microstructure allows the development of tissue culture media suitable for different cells. Polylactic acid (PLA) is a biobased and biodegradable (under...

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Published inFrontiers in chemistry Vol. 10; p. 1107620
Main Authors Chen, Tianyu, Zhao, Xiaoying, Weng, Yunxuan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.01.2023
Subjects
biomaterials
Chemistry
polylactic acid
self-assembly
surface microstructure
surface topography
self-assembly
polylactic acid
biomaterials
surface topography
surface microstructure
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Summary:The surface morphology and topography of cell culture substrates play an important role in cell proliferation and growth. Regulation of the surface microstructure allows the development of tissue culture media suitable for different cells. Polylactic acid (PLA) is a biobased and biodegradable (under defined conditions) polymer with low immunogenicity, non-toxicity, and good mechanical properties, which have facilitated their pharmaceutical and biomedical applications. This review summarizes recent advances in the synthesis and self-assembly of surface microstructure based on PLA materials and discusses their biomedical applications such as cell culturing and tissue engineering.
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Edited by: Wenhu Zhou, Central South University, China
This article was submitted to Supramolecular Chemistry, a section of the journal Frontiers in Chemistry
Hongchao Zhang, China Agricultural University, China
Reviewed by: Wenhu Zhan, iCarbonX, China
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.1107620