Smart stimuli-responsive drug delivery systems based on cyclodextrin: A review

• Published in: Carbohydrate polymers Vol. 251; p. 116871
• Main Authors: Tian, Bingren, Liu, Yumei, Liu, Jiayue
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2021
• Subjects: Biocompatible Materials; Clinic application; Clinical Trials as Topic; Cyclodextrin; cyclodextrins; Cyclodextrins - chemistry; developmental stages; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug delivery system; Drug Delivery Systems - classification; Drug Delivery Systems - methods; drugs; Enzymes - metabolism; Humans; Hydrogen-Ion Concentration; Light; magnetic materials; Magnetics; Materials Testing; medicine; Oxidation-Reduction; Photochemical Processes; Precise treatment; Stimuli-response; Temperature; therapeutics; CPT; DLS; DS; BSA; PTX; Rh; Clinic application; mAzo; Fc; Drug delivery system; CA; Precise treatment; CD; CUR; UV; Stimuli-response; GO; DOX; HP-β-CD; AAP; CS; Cyclodextrin; PEG; NIR; LCST; TEM; 5-FU
• ISSN: 0144-8617; 1879-1344; 1879-1344
• DOI: 10.1016/j.carbpol.2020.116871

[Display omitted] •Cyclodextrin is a smart tool to construct stimuli-responsive drug delivery systems.•Recent advances in smart stimuli-responsive cyclodextrin-based drug delivery are summarized.•Challenges and opportunities of smart stimuli-responsive drug delivery systems based on cyclodextrin are discussed. Stimulated by researches in materials chemistry and medicine fields, drug delivery has entered a new stage of development. Drug delivery systems have been extensively studied according to the differences in the drug therapeutic environment such as pH, light, temperature, magnet, redox, enzymes, etc. Cyclodextrin is a smart tool that has been proven to be used in the preparation of drug delivery, and has become a new area of concern in recent years. In this review, we discuss recent research advances in smart stimuli-responsive cyclodextrin-based drug delivery. First, different stimuli-responsive drug delivery systems based on cyclodextrin are introduced and classified. Then, the characteristics of different types of stimuli-responsive drug delivery systems are described, and their applications are emphasized. Finally, current challenges and future development opportunities of smart stimuli-responsive drug delivery systems based on cyclodextrin are discussed.