Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population

Metabolic syndrome encompasses multiple conditions that increase the risk of cardiovascular disease, and exposure to environmental chemicals can cause metabolic syndrome. This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey (2003–2006) on 4318 adult p...

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Published inInternational journal of environmental research and public health Vol. 18; no. 22; p. 11949
Main Authors Hung, Chun-Chi, Cheng, Yung-Wen, Chen, Wei-Liang, Fang, Wen-Hui
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 14.11.2021
MDPI
Subjects
Acrylamide
Angina pectoris
Blood pressure
Cardiovascular diseases
Cholesterol
Creatinine
Diabetes
Ethnicity
Exposure
Glucose
Health hazards
Health risks
Hemoglobin
High density lipoprotein
Hispanic people
Insulin resistance
Markers
Metabolic disorders
Metabolic syndrome
Metabolites
Neurotoxicity
Nutrition
Smoking
Triglycerides
Variance analysis
United States > US
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Summary:Metabolic syndrome encompasses multiple conditions that increase the risk of cardiovascular disease, and exposure to environmental chemicals can cause metabolic syndrome. This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey (2003–2006) on 4318 adult participants to assess the association between acrylamide (AA) exposure and metabolic syndrome. Concentrations of hemoglobin-adducted AA (HbAA) and hemoglobin-adducted glycidamide (HbGA) were evaluated. Metabolic syndrome markers related to HbAA and HbGA and the effect of exposure to AA and GA on the prevalence of metabolic syndrome were studied by ANOVA and multivariate logistic regression analyses, respectively. HbAA concentration inversely correlated with the number of metabolic syndrome markers (p < 0.05). An increased HbAA concentration was noted with reduced high triglyceride and low high-density lipoprotein cholesterol levels in the adjusted model (p < 0.05). High fasting plasma glucose level significantly correlated with HbGA concentration in the adjusted model. In conclusion, AA exposure alters metabolic syndrome markers in adults. Additional clinical and animal studies will clarify the role of AA exposure at different stages in the progression of metabolic syndrome-related diseases.
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ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph182211949