Clinicopathological and Prognostic Significance of Inhibitor of Apoptosis Protein (IAP) Family Members in Lung Cancer: A Meta-Analysis

Lung cancer is the most common cause of cancer-related death worldwide. Approximately 85% is non-small-cell and 15% is small-cell lung cancer. The inhibitor of apoptosis proteins (IAPs) represent a heterogeneous family of anti-apoptotic proteins, some members of which have been reported to correlate...

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Published inCancers Vol. 13; no. 16; p. 4098
Main Authors Fung, Stephen, Knoefel, Wolfram Trudo, Krieg, Andreas
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 14.08.2021
MDPI
Subjects
Apoptosis
Cancer therapies
Cell growth
Chemotherapy
Chromosomes
IAP protein
Kinases
Lung cancer
Lymph nodes
Lymphoma
Medical prognosis
Meta-analysis
Metastases
Metastasis
Mutation
Non-small cell lung carcinoma
Patients
Prognosis
Proteins
Survival analysis
Survivin
Systematic Review
Tumors
XIAP protein
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Summary:Lung cancer is the most common cause of cancer-related death worldwide. Approximately 85% is non-small-cell and 15% is small-cell lung cancer. The inhibitor of apoptosis proteins (IAPs) represent a heterogeneous family of anti-apoptotic proteins, some members of which have been reported to correlate with clinical outcome in lung cancer. We screened PubMed, Web of Science, and Scopus for studies that investigated the prognostic value and clinicopathological features of IAPs in lung cancer. Forty-five eligible studies with 4428 patients assessed the expression of the IAPs survivin, XIAP, livin, and BRUCE. The pooled hazard ratio (HR) of 33 studies that analyzed overall survival (OS) revealed a positive correlation between survivin expression and poor prognosis. Seven studies displayed a strong association between survivin and disease recurrence. Two studies that assessed the expression of XIAP and livin, respectively, proved a significant relationship of these IAPs with poor OS. Meta-analyses of clinicopathological variables revealed a significant association between survivin and T stage, UICC stage, the presence of lymph node metastasis, and grade of differentiation. In conclusion, high expression of distinct IAPs significantly correlates with prognosis in lung cancer. Therefore, lung cancer patients might benefit from a targeted therapy against specific IAPs.
Bibliography:ObjectType-Article-2
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13164098