Hyperglycemic Effects of a Periocular Dexamethasone Injection in Diabetic Patients after Vitreoretinal Surgery

• Published in: Biomedical and environmental sciences Vol. 25; no. 3; pp. 311 - 316
• Main Authors: ZHANG, Yong Peng, PENG, Xiao Yan, LI, Zhi Hua, CHEN, Feng Hua
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.06.2012; Beijing Ophthalmology and Visual Science Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital,Capital Medical University, Beijing 100730, China
• Subjects: 2型糖尿病; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - adverse effects; Blood glucose; Dexamethasone; Dexamethasone - administration & dosage; Dexamethasone - adverse effects; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Humans; Hyperglycemia - chemically induced; Injections, Intraocular; Periocular injection; Retrospective Studies; Vitreoretinal Surgery; 地塞米松; 患者; 手术; 注射液; 玻璃体; 视网膜; 高血糖; Vitreoretinal surgery; Blood glucose; Dexamethasone; Periocular injection; Diabetes mellitus
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/0895-3988.2012.03.009

Objective To examine the hyperglycemic effects of periocular dexamethasone injection in type 2 diabetic patients after vitreoretinal surgery （VRS）. Methods This was a retrospective non-randomized controlled trial. Twenty consecutive hospitalized patients with type 2 diabetes and ocular inflammatory reaction after VRS were enrolled in this study. Ten patients received 2.5 mg dexamethasone and 10 patients received 5 mg dexamethasone. Fourteen consecutive type 2 diabetic patients without ocular inflammatory reaction after VRS were used as control group. We measured fasting blood glucose （FBG） and at 2 h after each meal （post prandial glucose, PBG; 09：00, 13：00, and 19：00 h） after periocular dexamethasone injection. Differences among three groups were determined by q tests. Results The PBG levels in both dexamethasone-treated groups started to increase within 5 h after injection （i.e., PBG at 13：00 h）, and were significantly increased at 29：00 h after injection （P〈0.05）. BG levels were almost 2-fold higher than at baseline and compared with the control group. The BG values declined gradually by 24 h to 48 h after injection. There were no differences in BG levels between the two dexamethasone-treated groups （P〉0.05）, except for PBG at 19：00 h on day 2 after injection （P〈0.05）. Conclusion Periocular dexamethasone injection can cause transient hyperglycemia in diabetic patients after VRS. BG monitoring should be performed following such injection.