Myxobacteria--'microbial factories' for the production of bioactive secondary metabolites

In this article, we briefly review the potential of myxobacteria as 'natural product factories' by highlighting results from the recently sequenced myxobacterial model strain Myxococcus xanthus. We will focus on the production of polyketides, non-ribosomally-made peptides, and their hybrid...

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Bibliographic Details
Published inMolecular bioSystems Vol. 5; no. 6; pp. 567 - 574
Main Authors Wenzel, Silke C, Müller, Rolf
Format Journal Article
LanguageEnglish
Published England 01.01.2009
Subjects
Biosynthetic Pathways
Epothilones - biosynthesis
Epothilones - chemistry
Gene Expression Regulation, Bacterial
Genetic Engineering
Industrial Microbiology - methods
Macrolides - chemistry
Macrolides - metabolism
Myxobacteria
Myxococcales - genetics
Myxococcales - growth & development
Myxococcales - metabolism
Myxococcus xanthus
Myxococcus xanthus - genetics
Myxococcus xanthus - metabolism
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Summary:In this article, we briefly review the potential of myxobacteria as 'natural product factories' by highlighting results from the recently sequenced myxobacterial model strain Myxococcus xanthus. We will focus on the production of polyketides, non-ribosomally-made peptides, and their hybrids, and discuss the evaluation of biosynthetic potential using genome-based methods, as well as biosynthetic process engineering.
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ISSN:1742-206X
1742-2051
DOI:10.1039/b901287g