LONGITUDINAL SURVEY OF KNOCKDOWN RESISTANCE TO PYRETHROID (KDR) IN MALI, WEST AFRICA, AND EVIDENCE OF ITS EMERGENCE IN THE BAMAKO FORM OF ANOPHELES GAMBIAE S.S

Studies aimed at monitoring the spread of knockdown resistance to pyrethroids (kdr) in time and space are particularly useful for detecting barriers to gene flow among the chromosomal and molecular forms of Anopheles gambiae. We used a recently developed polymerase chain reaction assay to estimate c...

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Published inThe American journal of tropical medicine and hygiene Vol. 76; no. 1; pp. 81 - 87
Main Authors TRIPET, FREDERIC, WRIGHT, JENNIFER, CORNEL, ANTHON, FOFANA, ABDRAHAMANE, MCABEE, RORY, MENESES, CLAUDIO, REIMER, LISA, SLOTMAN, MICHEL, THIEMANN, TARA, DOLO, GUIMOGO, TRAORE, SEKOU, LANZARO, GREGORY
Format Journal Article
LanguageEnglish
Published Lawrence, KS ASTMH 01.01.2007
Allen Press
Subjects
Alleles
Animals
Anopheles - drug effects
Anopheles - genetics
Biological and medical sciences
Female
Infectious diseases
Insecticide Resistance - genetics
Mali
Medical sciences
Mosquito Control
Pyrethrins - pharmacology
Time Factors
Mali
West Africa
Africa
Resistance
Insecticide
Anopheles gambiae
Arthropoda
Insecta
Culicidae
Pesticides
Pyrethroids
Tropical medicine
Invertebrata
Diptera
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Summary:Studies aimed at monitoring the spread of knockdown resistance to pyrethroids (kdr) in time and space are particularly useful for detecting barriers to gene flow among the chromosomal and molecular forms of Anopheles gambiae. We used a recently developed polymerase chain reaction assay to estimate changes in kdr frequency that occurred in several mixed-form populations from Mali, West Africa, in the past decade. We found that the kdr allele significantly increased in frequency in most populations but was still absent from the M molecular form. Importantly, within the S molecular form, kdr was detected for the first time in the Bamako chromosomal form. These results provide important insights on the patterns of spread and emergence of pyrethroid knockdown resistance in West Africa.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2007.76.81