Kinetics of Ligand Binding to Nucleic Acids

Ligand binding to nucleic acids (NA) is considered as a stationaiy Markov process. It is shown that the probabilistic description of ligand-NA binding allows one to describe not only the kinetics of the change of number of bound ligands at arbitrary fillings but also to calculate stationaiy values o...

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Bibliographic Details
Published inJournal of biomolecular structure & dynamics Vol. 23; no. 4; pp. 479 - 483
Main Authors Arakelyan, V. B., Babayan, S. Yu, Tairyan, V. I., Arakelyan, A. V., Parsadanyan, M. A., Vardevanyan, P. O.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.02.2006
Subjects
Kinetics
Ligands
Markov Chains
Models, Biological
Nucleic Acids - chemistry
Nucleic Acids - metabolism
Thermodynamics
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Summary:Ligand binding to nucleic acids (NA) is considered as a stationaiy Markov process. It is shown that the probabilistic description of ligand-NA binding allows one to describe not only the kinetics of the change of number of bound ligands at arbitrary fillings but also to calculate stationaiy values of the number of bound ligands and its dispersion. The general analysis of absoiption isotherms and kinetics of ligand binding to NA make it possible to determine of rate constants of ligand-NA complex formation and dissociation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0739-1102
1538-0254
DOI:10.1080/07391102.2006.10507073