Atopic diathesis in hypohidrotic/anhidrotic ectodermal dysplasia

• Published in: Acta dermato-venereologica Vol. 95; no. 4; pp. 476 - 479
• Main Authors: Koguchi-Yoshioka, Hanako, Wataya-Kaneda, Mari, Yutani, Mizuki, Murota, Hiroyuki, Nakano, Hajime, Sawamura, Daisuke, Katayama, Ichiro
• Format: Journal Article
• Language: English
• Published: Sweden 01.04.2015
• Subjects: Adolescent; Adult; Child; Child, Preschool; Dermatitis, Atopic - complications; Dermatitis, Atopic - metabolism; Ectodermal Dysplasia - complications; Ectodermal Dysplasia - metabolism; Female; Humans; Hypohidrosis; Immunoglobulin E - blood; Infant; Intermediate Filament Proteins - metabolism; Male; Staining and Labeling; Sweat Glands - abnormalities; Young Adult
• ISSN: 0001-5555; 1651-2057
• DOI: 10.2340/00015555-1978

Recently, patients with hypohidrotic/anhidrotic ectodermal dysplasia (H/AED) have been reported to have a higher prevalence of symptoms suggestive of atopic disorders than the general population. To better understand atopic diathesis in H/AED, 6 cases of clinically or genetically diagnosed H/AED were examined. The following criteria were evaluated with patient consent: sweating, blood test results, histopathology and filaggrin staining. Five of 6 H/AED cases displayed atopic dermatitis-like manifestations, and 3 of these 5 cases experienced periorbital lesions. H/AED patients tended to present with atopic dermatitis-like eruptions with characteristics potentially indicative of periorbital lesions. Atopic diathesis in H/AED appeared not to be associated with filaggrin. We could speculate that hypohidrosis or anhidrosis itself might impair skin barrier function and contribute to atopic diathesis.