Emotion-induced amnesia in rats: working memory-specific impairment, corticosterone-memory correlation, and fear versus arousal effects on memory

• Published in: Learning & memory (Cold Spring Harbor, N.Y.) Vol. 10; no. 5; pp. 326 - 336
• Main Authors: Woodson, James C, Macintosh, Deric, Fleshner, Monika, Diamond, David M
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.09.2003
• Subjects: Amnesia - physiopathology; Animals; Arousal - physiology; Corticosterone - blood; Corticosterone - physiology; Emotions - physiology; Fear - physiology; Fear - psychology; Hippocampus - physiology; Linear Models; Male; Memory - physiology; Memory, Short-Term - physiology; Rats; Rats, Sprague-Dawley; Research Papers; Stress, Psychological - physiopathology
• ISSN: 1072-0502; 1549-5485
• DOI: 10.1101/lm.62903

We have shown previously that psychological stress (predator exposure) impairs spatial memory in rats. We have extended that finding here to show that predator stress selectively impaired recently acquired (hippocampal-dependent) spatial working memory without affecting long-term (hippocampal-independent) spatial reference memory. We also investigated why predator exposure impairs memory. Was spatial memory impaired because of the fear-provoking aspects of predator exposure or only because the cat was a novel and arousing stimulus? If the latter possibility was correct, then any novel and arousing stimulus, independent of its emotional valence (i.e., aversive or appetitive), would impair memory. We found that spatial working memory was not impaired when the male rats were exposed to a sexually receptive female rat, a stimulus that was novel and arousing to them, but not aversive. We also found that there was an equivalent increase in serum corticosterone levels in male rats exposed to either a cat or a female rat, but only the cat-exposed rats exhibited a significant correlation between corticosterone levels and impaired memory. Overall, this series of experiments demonstrates that (1). predator stress selectively impaired working (hippocampal-dependent), but not reference (hippocampal-independent), memory; (2). a fear-provoking stimulus, and not merely novelty and increased arousal, impaired spatial memory; and (3). increased corticosterone levels correlated with impaired spatial working memory only under predator exposure, that is, fear-provoking conditions.