Caffeine: A novel green precursor for synthesis of magnetic CoFe2O4 nanoparticles and pH-sensitive magnetic alginate beads for drug delivery

• Published in: Materials Science & Engineering C Vol. 76; pp. 1085 - 1093
• Main Authors: Amiri, Mahnaz, Salavati-Niasari, Masoud, Pardakhty, Abbas, Ahmadi, Meysam, Akbari, Ahmad
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 01.07.2017; Elsevier BV
• Subjects: Alginate; Alginic acid; Beads; Biocompatibility; Biopolymers; Caffeine; Calcium; Cell lines; Chlorpheniramine maleate; Cobalt ferrites; CoFe2O4 nanostructures; Crosslinking; Cytotoxicity; Drug delivery systems; Fabrication; Hydrogels; Magnetic beads; Materials science; Nanoparticles; Nanostructured materials; pH effects; Precursors; Sodium alginate; Swelling ratio; Toxicity testing; Magnetic beads; Cytotoxicity; Alginate; CoFe2O4 nanostructures; Chlorpheniramine maleate; Caffeine
• ISSN: 0928-4931; 1873-0191; 1873-0191
• DOI: 10.1016/j.msec.2017.03.208

Hydrogel beads are promising delivery systems for encapsulation and release of drugs due to the mild process of their fabrication from biopolymers. Magnetic CoFe2O4 nanoparticles (MCFO, 9.72nm in diameter) were synthesized via a co-precipitation method using caffeine as a new environmentally friendly material in order to alkalinize the medium. Drug-targeting Magnetic beads based on CoFe2O4 nanoparticles, sodium alginate and chlorpheniramine maleate (CPAM) were synthesized in the presence of Ca2+ ions to obtain ionic cross-linked magnetic hydrogel beads. Nanoparticles as well as produced magnetic beads were thoroughly characterized by FTIR, XRD, SEM, nanosizer and VSM techniques. The swelling ratio of beads indicated pH-dependent property with maximum water absorbing at pH7.4. The in vitro release of beads exhibited significant behavior on the subject of nanoparticles concentration and alginate content. Biocompatibility of the CFO nanoparticles and MCFO/Alg beads are demonstrated through cytotoxicity test via MTT assay on U87 cell lines. [Display omitted] •Magnetic CoFe2O4 nanostructures (MCFO) were prepared in the presence of caffeine.•MCFO/CPAM/alginate beads with controlled drug release property showed pH-dependent.•Trapping the CPAM inside the carbon and cavities of magnetic beads makes more gradually drug release.•Prepared beads because of acceptable biocompatibility have potential applications in biomedical.