Effects of tissue plasminogen activator on medium-term functional independence: A propensity score-matched analysis

• Published in: Medicine (Baltimore) Vol. 101; no. 41; p. e31108
• Main Authors: Kakinuma, Tomohiro, Fujita, Takaaki, Iwamoto, Tetsuya, Mizushiri, Tsuyoshi, Yazawa, Yukako
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 14.10.2022
• Subjects: Observational Study
• ISSN: 1536-5964; 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000031108

This study revealed the effects of tissue plasminogen activator (tPA) on medium-term functional independence in patients with stroke. We retrospectively examined 240 patients from April 2016 to March 2019 and selected 68 who met our criteria. After adjusting the functional status at the onset by propensity score matching, the functional independence measure (FIM) on admission to and discharge from the convalescent rehabilitation wards was compared between the groups classified by the presence or absence of tPA. Twelve pairs were derived by propensity score matching. Upon admission to the convalescent rehabilitation ward, the median score of the FIM was significantly higher in the tPA group than in the non-tPA group ( P = .028). Patients in the tPA group had higher median FIM scores at discharge than those in the non-tPA group ( P = .060). The difference in the independence level of activities of daily living (ADL) between the groups with and without tPA may gradually decrease with continuous inpatient rehabilitation. However, the tPA group tended to have high levels of independence in ADL at the time of discharge.