The influence of spontaneous and induced labour on the rise in prostaglandins at amniotomy

Maternal peripheral plasma levels of 13,14-dihydro-15-keto-prostaglandin F (PGFM) were measured immediately before and 5 min after amniotomy. Three groups of women were studied: women in late pregnancy; women in spontaneous labour; and women who had received intravaginal prostaglandin E2 (PGE2) pess...

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Bibliographic Details
Published inBritish journal of obstetrics and gynaecology Vol. 91; no. 9; p. 849
Main Authors Sellers, S M, Mitchell, M D, Anderson, A B, Turnbull, A C
Format Journal Article
LanguageEnglish
Published England 01.09.1984
Subjects
Adult
Dinoprost - analogs & derivatives
Dinoprostone
Female
Humans
Labor, Induced
Labor, Obstetric
Pessaries
Pregnancy
Pregnancy Trimester, Third
Prostaglandins E - administration & dosage
Prostaglandins F - blood
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Summary:Maternal peripheral plasma levels of 13,14-dihydro-15-keto-prostaglandin F (PGFM) were measured immediately before and 5 min after amniotomy. Three groups of women were studied: women in late pregnancy; women in spontaneous labour; and women who had received intravaginal prostaglandin E2 (PGE2) pessary. There was no significant difference in the magnitude of the rise in PGFM after amniotomy in late pregnancy or during spontaneous labour suggesting that labour has no influence on the release of prostaglandin F2 alpha (PGF2 alpha) induced by artificial rupture of the fetal membranes. However, local administration of PGE2 before amniotomy caused a greater rise in PGFM suggesting that PGE2 can influence the release and/or metabolism of PGF2 alpha.
ISSN:0306-5456
DOI:10.1111/j.1471-0528.1984.tb03695.x