Congenital apocrine hamartoma: an unusual clinical variant of organoid nevus with apocrine differentiation

Congenital apocrine hamartomas are rare tumors of the skin composed of mature apocrine glands in the papillary and reticular dermis. Several cases have been reported in the literature but few were of uniform clinical appearance. The term apocrine nevus has been used interchangeably with apocrine ham...

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Bibliographic Details
Published inPediatric dermatology Vol. 12; no. 3; p. 248
Main Authors Herrmann, J J, Eramo, L R
Format Journal Article
LanguageEnglish
Published United States 01.09.1995
Subjects
Child
Facial Neoplasms - congenital
Facial Neoplasms - pathology
Female
Hamartoma - pathology
Humans
Nevus - congenital
Nevus - pathology
Sweat Gland Diseases - congenital
Sweat Gland Diseases - pathology
Sweat Gland Neoplasms - congenital
Sweat Gland Neoplasms - pathology
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Summary:Congenital apocrine hamartomas are rare tumors of the skin composed of mature apocrine glands in the papillary and reticular dermis. Several cases have been reported in the literature but few were of uniform clinical appearance. The term apocrine nevus has been used interchangeably with apocrine hamartoma in the literature, however, based on their distinctive morphologies we believe they are different entities. We describe a 7-year-old girl with a congenital apocrine hamartoma of the left cheek. A stained biopsy specimen from the lesion revealed large mature apocrine glands with decapitation secretion in the dermis. The presence of periodic acid-Schiff-positive, diastase-resistant granular material in the apical cytoplasm of some secretory cells helped differentiate these as apocrine glands. We think this lesion may represent a form of organoid nevus with pure apocrine differentiation.
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1995.tb00170.x